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dc.contributor.author
Borge, Mercedes
dc.contributor.author
Nannini, Paula Romina
dc.contributor.author
Galletti, Jeremías Gastón
dc.contributor.author
Morande, Pablo Elías
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Sánchez Ávalos, Julio César Américo
dc.contributor.author
Bezares, Raimundo Fernando
dc.contributor.author
Giordano, Mirta Nilda
dc.contributor.author
Gamberale, Romina
dc.date.available
2019-12-13T19:48:53Z
dc.date.issued
2010-05
dc.identifier.citation
Borge, Mercedes; Nannini, Paula Romina; Galletti, Jeremías Gastón; Morande, Pablo Elías; Sánchez Ávalos, Julio César Américo; et al.; CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia; Ferrata Storti Foundation; Haematologica; 95; 5; 5-2010; 768-775
dc.identifier.issn
0390-6078
dc.identifier.uri
http://hdl.handle.net/11336/92224
dc.description.abstract
Background T cells from patients with chronic lymphocytic leukemia may play an important role in contributing to the onset, sustenance, and exacerbation of the disease by providing survival and proliferative signals to the leukemic clone within lymph nodes and bone marrow. Design and Methods By performing chemotaxis assays towards CXCL12, CCL21 and CCL19, we sought to evaluate the migratory potential of T cells from chronic lymphocytic leukemia patients. We next analyzed the chemokine-induced migration of T cells, dividing the chronic lymphocytic leukemia samples according to their expression of the poor prognostic factors CD38 and ZAP70 in leukemic cells determined by flow cytometry. Results We found that T cells from patients with chronic lymphocytic leukemia are less responsive to CXCL12, CCL21 and CCL19 than T cells from healthy adults despite similar CXCR4 and CCR7 expression. Following separation of the patients into two groups according to ZAP-70 expression, we found that T cells from ZAP-70-negative samples showed significantly less migration towards CXCL12 compared to T cells from ZAP-70-positive samples and that this was not due to defective CXCR4 down-regulation, F-actin polymerization or to a lesser expression of ZAP-70, CD3, CD45, CD38 or CXCR7 on these cells. Interestingly, we found that leukemic cells from ZAP-70-negative samples seem to be responsible for the defective CXCR4 migratory response observed in their T cells. Conclusions Impaired migration towards CXCL12 may reduce the access of T cells from ZAP-70-negative patients to lymphoid organs, creating a less favorable microenvironment for leukemic cell survival and proliferation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Ferrata Storti Foundation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC LYMPHOCYTIC LEUKEMIA
dc.subject
CXCL12
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CXCR4
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T-CELL CHEMOTAXIS
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T19:31:45Z
dc.identifier.eissn
1592-8721
dc.journal.volume
95
dc.journal.number
5
dc.journal.pagination
768-775
dc.journal.pais
Italia
dc.journal.ciudad
Pavia
dc.description.fil
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Nannini, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Sánchez Ávalos, Julio César Américo. Instituto Alexander Fleming; Argentina
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Fil: Bezares, Raimundo Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
dc.description.fil
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Haematologica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/content/95/5/768
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3324/haematol.2009.013995
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