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dc.contributor.author
Fletcher, Sabrina Johanna
dc.contributor.author
Hapon, María Belén
dc.contributor.author
Callegari, E.
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Crosbie, M. L.
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Santiso, N.
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Ursino, A.
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Amato, A. R.
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Gutiérrez, A.
dc.contributor.author
Sacca, Paula Alejandra
dc.contributor.author
Dreszman, R.
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Pérez, A.
dc.contributor.author
Caron, Ruben Walter
dc.contributor.author
Calvo, Juan Carlos
dc.contributor.author
Pistone Creydt, Virginia
dc.date.available
2019-12-12T19:30:31Z
dc.date.issued
2018-07
dc.identifier.citation
Fletcher, Sabrina Johanna; Hapon, María Belén; Callegari, E.; Crosbie, M. L.; Santiso, N.; et al.; Comparative proteomics of soluble factors secreted by human breast adipose tissue from tumor and normal breast; Impact Journals LLC; Oncotarget; 9; 57; 7-2018; 31007-31017
dc.identifier.issn
1949-2553
dc.identifier.uri
http://hdl.handle.net/11336/92113
dc.description.abstract
Tumor progression depends on the tumor-stroma interaction. In the breast, adipose tissue is the predominant stromal type. We have previously demonstrated that conditioned media (CMs) from explants of human adipose tissue of tumor breasts (hATT) increase proliferation and migration of breast cancer epithelial cells when compared to human adipose tissue from normal breasts (hATN). In this work, we aim to identify specific proteins and molecular/biological pathways associated with the secretion profile of hATT and hATN explants. hATT-CMs and hATN-CMs were separated by SDS-PAGE and analyzed by means of two-dimensional nano-liquid chromatography-mass spectrometry. The data was analyzed using ProteoIQ and FunRich software. In addition, 42 cytokines from hATTCMs and hATN-CMs were assayed by a protein antibody assay. Compared to hATNCMs, hATT-CMs showed greater protein diversity. We found that hATT-CMs presented a greater amount of proteins related to complement system activity, metabolism and immune system, as well as proteins involved in a variety of biological processes such as signal transduction and cell communication. Specifically, apolipoprotein AI and AII, complement component 3, and vimentin and desmin were significantly increased in hATT-CMs versus hATN-CMs. Moreover, a multivariate discriminant analysis of the cytokines detected by the array showed that IL-6, MCP-2 and GRO cytokines were sufficient and necessary to differentiate hATT-CMs from hATN-CMs. This analysis also showed that the levels of these three cytokines, taken together, correlated with stage and histological grade of the tumor in the hATT-CMs group, and with body mass index in the hATN-CMs group.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Impact Journals LLC
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADIPOSE TISSUE
dc.subject
EPITHELIAL-STROMAL INTERACTION
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HUMAN BREAST CANCER
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PROTEOMICS ANALYSIS
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TUMOR MICROENVIRONMENT
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Comparative proteomics of soluble factors secreted by human breast adipose tissue from tumor and normal breast
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-17T15:44:09Z
dc.journal.volume
9
dc.journal.number
57
dc.journal.pagination
31007-31017
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Albany
dc.description.fil
Fil: Fletcher, Sabrina Johanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Callegari, E.. University Of South Dakota; Estados Unidos
dc.description.fil
Fil: Crosbie, M. L.. Complejo Médico Policial "Churruca Visca"; Argentina
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Fil: Santiso, N.. Complejo Médico Policial "Churruca Visca"; Argentina
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Fil: Ursino, A.. Complejo Médico Policial "Churruca Visca"; Argentina
dc.description.fil
Fil: Amato, A. R.. Complejo Médico Policial "Churruca Visca"; Argentina
dc.description.fil
Fil: Gutiérrez, A.. Complejo Médico Policial "Churruca Visca"; Argentina
dc.description.fil
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Dreszman, R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Pérez, A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina
dc.description.fil
Fil: Caron, Ruben Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Pistone Creydt, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Oncotarget
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/oncotarget.25749
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25749&path[]=80555
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