Artículo
Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test
Gargiulo, Augusto P. I.; Gargiulo De Aranda, María P.; Gargiulo, Mercedes Maria Lucrecia; Gargiulo, Ángel José Martín; Acuña, Andres
; Baiardi, Gustavo Carlos
; Lafuente, José V.; Landa De Gargiulo, Adriana I.; Guevara, Manuel Alejandro; Gargiulo, Pascual Angel
Fecha de publicación:
06/2018
Editorial:
De Gruyter
Revista:
Journal of Basic and Clinical Physiology and Pharmacology
ISSN:
2191-0286
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In previous studies, we have observed that specific N-methyl-d-Aspartic acid (NMDA) antagonists and non-NMDA antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the plus maze test in rats. In the present study, the effect of intracanalicular blockade of NMDA receptors using dizocilpine in the plus maze was studied in male rats bilaterally cannulated NAS. Rats were divided into five groups that received either 1 μL injections of saline or dizocilpine (MK-801, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine) in different doses (0.5, 1, 2, or 4 μg) 15 min before testing. Time spent in the open arm increased under dizocilpine treatment with the two higher doses (2 and 4 μg, p<0.05), extreme arrivals were increased by the three higher doses (1 μg, p<0.05; 2 and 4 μg, p<0.01), and open arm entries by the three higher doses (1, 2, and 4 μg, p<0.05). A dose-effect relationship was observed in all cases. We conclude that dizocilpine-glutamatergic blockade in the accumbens lead to an anxiolytic-like effect and a behavioral disinhibition related to an increase in some motoric parameters, showing specific behavioral patterns.
Palabras clave:
ACCUMBENS
,
ANXIETY
,
DIZOCILPINE
,
PLUS MAZE
,
RAT
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - MENDOZA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MENDOZA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MENDOZA
Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Citación
Gargiulo, Augusto P. I.; Gargiulo De Aranda, María P.; Gargiulo, Mercedes Maria Lucrecia; Gargiulo, Ángel José Martín; Acuña, Andres; et al.; Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test; De Gruyter; Journal of Basic and Clinical Physiology and Pharmacology; 29; 3; 6-2018; 241-246
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