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Artículo

Evaluation of antimicrobial activity of glycerol monolaurate nanocapsules against American foulbrood disease agent and toxicity on bees

Lopes, Leonardo Q.S.; Santos, Cayane G.; de Almeida Vaucher, Rodrigo; Gende, Liesel BrendaIcon ; Raffin, Renata P.; Santos, Roberto C.V.
Fecha de publicación: 08/2016
Editorial: Academic Press Ltd - Elsevier Science Ltd
Revista: Microbial Pathogenesis
ISSN: 0882-4010
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

The American Foulbrood Disease (AFB) is a fatal larval bee infection. The etiologic agent is the bacterium Paenibacillus larvae. The treatment involves incineration of all contaminated materials, leading to high losses. The Glycerol Monolaurate (GML) is a known antimicrobial potential compound, however its use is reduced due to its low solubility in water and high melting point. The nanoencapsulation of some drugs offers several advantages like improved stability and solubility in water. The present study aimed to evaluate the antimicrobial activity against P. larvae and the toxicity in bees of GML nanoparticles. The nanocapsules were produced and presented mean diameter of 210 nm, polydispersity index of 0.044, and zeta potential of −23.4 mV demonstrating the acceptable values to predict a stable system. The microdilution assay showed that it is necessary 142 and 285 μg/mL of GML nanocapsules to obtain a bacteriostatic and bactericidal effect respectively. The time-kill curve showed the controlled release of compound, exterminating the microorganism after 24 h. The GML nanocapsules were able to kill the spore form of Paenibacillus larvae while the GML do not cause any effect. The assay in bees showed that the GML has a high toxicity while the GML nanoparticles showed a decrease on toxic effects. Concluding, the formulation shows positive results in the action to combat AFB besides not causing damage to bees.
Palabras clave: ANTIMICROBIAL ACTIVITY , BEEHIVES , NANOPARTICLE , TOXICITY
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/92091
URL: https://www.sciencedirect.com/science/article/pii/S0882401016301516
DOI: http://dx.doi.org/10.1016/j.micpath.2016.05.014
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Articulos(CCT - MAR DEL PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MAR DEL PLATA
Citación
Lopes, Leonardo Q.S.; Santos, Cayane G.; de Almeida Vaucher, Rodrigo; Gende, Liesel Brenda; Raffin, Renata P.; et al.; Evaluation of antimicrobial activity of glycerol monolaurate nanocapsules against American foulbrood disease agent and toxicity on bees; Academic Press Ltd - Elsevier Science Ltd; Microbial Pathogenesis; 97; 8-2016; 183-188
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