Artículo
Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release
Fecha de publicación:
10/07/2018
Editorial:
Elsevier Science
Revista:
International Journal Of Pharmaceutics
ISSN:
0378-5173
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Polysaccharides-based delivery systems and interpolyelectrolyte complexes (IPECs) are interesting alternatives to control the release of drugs, thereby improving therapies. Benznidazole (BZ) is the selected drug for Chagas disease pharmacotherapy. However, its side effects limit its efficacy and safety. We developed novel multiparticulated BZ-loaded IPECs based on chitosan and alginic acid, and investigated their physicochemical and pharmacotechnical properties. IPECs were obtained using the casting solvent method, followed by wet granulation. They presented ionic interaction between the biopolymers, revealed that free BZ was uniformly distributed and showed adequate flow properties for hard gelatin-capsule formulation. The multiparticles exhibited mucoadhesion properties and revealed modulation of BZ release, depending on the release media, in accordance with the fluid uptake. The IPECs developed possess interesting properties that are promising for the design of novel alternatives to improve Chagas disease pharmacotherapy, which would diminish BZ's adverse effects and/or allow a reduction in the frequency of BZ administration.
Palabras clave:
ALGINIC ACID
,
BENZNIDAZOLE
,
CHITOSAN
,
DRUG DELIVERY
,
POLYELECTROLYTE COMPLEXES
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Licencia
Identificadores
Colecciones
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
García, Mónica Cristina; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico; Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release; Elsevier Science; International Journal Of Pharmaceutics; 545; 1-2; 10-7-2018; 366-377
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