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Artículo

Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment

Cacicedo, Maximiliano LuisIcon ; Islan, German AbelIcon ; Leon, Ignacio EstebanIcon ; Alvarez, Vera AlejandraIcon ; Chourpa, Igor; Allard Vannier, E.; García Aranda, N.; Díaz Riascos, Z.V.; Fernández, Y.; Schwartz, S.; Abasolo, Ibane; Castro, Guillermo RaulIcon
Fecha de publicación: 10/2018
Editorial: Elsevier Science
Revista: Colloids and Surfaces B: Biointerfaces
ISSN: 0927-7765
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Nano-materiales

Resumen

The use of hybrid materials, where a matrix sustains nanoparticles controlling the release of the chemotherapeutic drug, could be beneficial for the treatment of primary tumors prior or after surgery. This localized chemotherapy would guarantee high drug concentrations at the tumor site while precluding systemic drug exposure minimizing undesirable side effects. We combined bacterial cellulose hydrogel (BC) and nanostructured lipid carriers (NLCs) including doxorubicin (Dox) as a drug model. NLCs loaded with cationic Dox (NLCs-H) or neutral Dox (NLCs-N) were fully characterized and their cell internalization and cytotoxic efficacy were evaluated in vitro against MDA-MB-231 cells. Thereafter, a fixed combination of NLCs-H and NLCs-N loaded into BC (BC-NLCs-NH) was assayed in vivo into an orthotopic breast cancer mouse model. NLCs-H showed low encapsulation efficiency (48%) and fast release of the drug while NLCs-N showed higher encapsulation (97%) and sustained drug release. Both NLCs internalized via endocytic pathway, while allowing a sustained release of the Dox, which in turn rendered IC50 values below of those of free Dox. Taking advantage of the differential drug release, a mixture of NLCs-N and NLCs-H was encapsulated into BC matrix (BC-NLCs-NH) and assayed in vivo, showing a significant reduction of tumor growth, metastasis incidence and local drug toxicities.
Palabras clave: BACTERIAL CELLULOSE , BREAST CANCER , CONTROLLED RELEASE , DOXORUBICIN , DRUG DELIVERY , HYDROGEL , LOCALIZED CHEMOTHERAPY , NANOCOMPOSITE , NANOSTRUCTURED LIPID CARRIERS , NEO-ADJUVANT THERAPY
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/91815
URL: https://www.sciencedirect.com/science/article/pii/S0927776518304272
DOI: http://dx.doi.org/10.1016/j.colsurfb.2018.06.056
Colecciones
Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Articulos(CINDEFI)
Articulos de CENT.DE INV EN FERMENTACIONES INDUSTRIALES (I)
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Cacicedo, Maximiliano Luis; Islan, German Abel; Leon, Ignacio Esteban; Alvarez, Vera Alejandra; Chourpa, Igor; et al.; Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 170; 10-2018; 596-608
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