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dc.contributor.author
Vega Royero, Shirlene Patricia
dc.contributor.author
Sibona, Gustavo Javier
dc.date.available
2019-12-05T22:52:26Z
dc.date.issued
2018-09
dc.identifier.citation
Vega Royero, Shirlene Patricia; Sibona, Gustavo Javier; Who benefits from cellular immune response during the Chagas disease?; Elsevier; Biosystems; 171; 9-2018; 66-73
dc.identifier.issn
0303-2647
dc.identifier.uri
http://hdl.handle.net/11336/91572
dc.description.abstract
We extend our previous model for the dynamical interaction between a mammal's immune response and the Trypanosoma cruzi parasite during the acute phase of Chagas disease. The model here considers both humoral and cellular responses and the different stages of T. cruzi (intracellular and extracellular phases) inside the mammal host. We analyze the dynamical time evolution of the populations obtaining phase diagrams of the model results. The steady-state solution of the system yields two outcomes associated to Healing and Chronic stationary cases, the death case obtained when just the humoral immune response alone was considered is not being present. This result implies that, surprisingly, although the immune cellular response is obviously beneficial for the host, it is also evolutionary advantageous for the parasite, as it helps to preserve the host alive and, after transmission to a healthy host, perpetuate the disease. Of course, if the cell damage by the parasite's intracellular stage is high, it may cause the host death. This possibility is accounted in the model by introducing a death criterion related to cell destruction. We present a new phase diagram, that restores the host death case and generates a phase diagram similar to the one arising from the original model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHAGAS DISEASE
dc.subject
IMMUNE REACTION
dc.subject
PARASITEMIA
dc.subject
TRYPANOSOMIASIS
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Who benefits from cellular immune response during the Chagas disease?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T16:43:43Z
dc.journal.volume
171
dc.journal.pagination
66-73
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Vega Royero, Shirlene Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Católica Luis Amigó; Colombia
dc.description.fil
Fil: Sibona, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.journal.title
Biosystems
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biosystems.2018.07.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303264717302253?via%3Dihub
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