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Artículo

Glutathione depleting drugs, antioxidants and intestinal calcium absorption

Moine, Luciana BeatrizIcon ; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori GracielaIcon
Fecha de publicación: 02/11/2018
Editorial: W J G Press
Revista: World Journal of Gastroenterology
ISSN: 1007-9327
e-ISSN: 2219-2840
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.
Palabras clave: DL-BUTHIONINE-S,R-SULFOXIMINE , FRUCTOSE RICH DIET , GLUTAMINE , GLUTATHIONE , MELATONIN , MENADIONE , NARINGIN , QUERCETIN , SODIUM DEOXYCHOLATE , TRANSCELLULAR AND PARACELLULAR CA2+PATHWAYS , URSODEOXYCHOLIC ACID
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/91553
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262252/
URL: https://www.wjgnet.com/1007-9327/full/v24/i44/4979.htm
DOI: http://dx.doi.org/10.3748/wjg.v24.i44.4979
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Moine, Luciana Beatriz; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori Graciela; Glutathione depleting drugs, antioxidants and intestinal calcium absorption; W J G Press; World Journal of Gastroenterology; 24; 44; 2-11-2018; 4979-4988
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