Artículo
Anti-glioma properties of DVL, a lectin purified from Dioclea violacea
Nascimento, Ana Paula M.; Knaut, Jhônatas L.; Rieger, Débora K.; Wolin, Ingrid A.V.; Heinrich, Isabella A.; Mann, Josiane; Juarez, Andrea Virginia
; Sosa, Liliana del Valle
; de Paul, Ana Lucia
; Moreira, Cleane G.; Silva, Ivanice B.; Nobre, Clareane S.; Osterne, Vinicius J.S.; Nascimento, Kyria S.; Cavada, Benildo S.; Leal, Rodrigo B.
Fecha de publicación:
12/2018
Editorial:
Elsevier Science
Revista:
International Journal of Biological Macromolecules
ISSN:
0141-8130
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Plant lectins have been studied owing to their structural properties and biological effects that include agglutinating activity, antidepressant-like effect and antitumor property. The results from this work showed the effects of the lectin extracted from the Dioclea violacea plant (DVL) on the C6 rat glioma cell line. DVL treatment was able to induce caspase-3 activation, apoptotic cell death and cellular membrane damage. Furthermore, DVL decreased mitochondrial membrane potential and increased the number of acidic vesicles and cleavage of LC3, indicating activation of autophagic processes. DVL also significantly inhibited cell migration. Compared to ConA, a well-studied lectin extracted from Canavalia ensiformes seeds, some effects of DVL were more potent, including decreasing C6 glioma cell viability and migration ability. Taken together, the results suggest that DVL can induce glioma cell death, autophagy and inhibition of cell migration, displaying potential anti-glioma activity.
Palabras clave:
AUTOPHAGY
,
CONA
,
DIOCLEA VIOLACEA
,
DVL
,
GLIOMA
,
LECTIN
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Nascimento, Ana Paula M.; Knaut, Jhônatas L.; Rieger, Débora K.; Wolin, Ingrid A.V.; Heinrich, Isabella A.; et al.; Anti-glioma properties of DVL, a lectin purified from Dioclea violacea; Elsevier Science; International Journal of Biological Macromolecules; 120; 12-2018; 566-577
Compartir
Altmétricas