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dc.contributor.author
Torres, Pedro Javier  
dc.contributor.author
Luque, Eugenia Mercedes  
dc.contributor.author
Ponzio, Marina Flavia  
dc.contributor.author
Cantarelli, Verónica Inés  
dc.contributor.author
Diez, Marcela  
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Figueroa, S.  
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Vincenti, Laura María  
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Carlini, Valeria Paola  
dc.contributor.author
Martini, Ana Carolina  
dc.date.available
2019-12-05T17:57:02Z  
dc.date.issued
2018-05  
dc.identifier.citation
Torres, Pedro Javier; Luque, Eugenia Mercedes; Ponzio, Marina Flavia; Cantarelli, Verónica Inés; Diez, Marcela; et al.; The role of intragestational ghrelin on postnatal development and reproductive programming in mice; BioScientifica; Reproduction; 156; 4; 5-2018; 331-351  
dc.identifier.issn
1470-1626  
dc.identifier.uri
http://hdl.handle.net/11336/91504  
dc.description.abstract
The purpose of this study was to evaluate the intragestational role of ghrelin in offspring development and reproductive programming in a mouse model of ghrelin imbalance during pregnancy. Female mice were injected with ghrelin (supraphysiological levels: 4 nmol/animal/day), antagonist (endogenous ghrelin inhibition with (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control = normal ghrelin levels) throughout the pregnancy. Parameters evaluated in litters were growth, physical, neurobiological and sexual development and, at adulthood, reproductive function. Litter size and initial weight did not vary between treatments. Male pups from dams treated with ghrelin showed higher body weight increase until adulthood (31.7 ± 0.8 vs control = 29.7 ± 0.7, n = 11-14 litters/treatment; P < 0.05). Postnatal physical and neurobiological development was not modified by treatments. The antagonist accelerated male puberty onset, evidenced as earlier testis descent and increased relative testicular weight (antagonist = 0.5 ± 0.0% vs ghrelin = 0.4 ± 0.0% and control = 0.4 ± 0.0%, n = 5-10 litters/treatment; P < 0.05). At adulthood, these males exhibited lower relative testicular weight and reduced sperm motility (63.9 ± 3.6% vs control = 70.9 ± 3.3 and ghrelin = 75.6 ± 3.0, n = 13-15 animals; P < 0.05), without changes in plasma testosterone or fertility. Female pups intragestationally exposed to the antagonist showed earlier vaginal opening (statistically significant only at Day 25) and higher ovarian volume (antagonist = 1085.7 ± 64.0 mm3 vs ghrelin = 663.3 ± 102.8 mm3 and control = 512.3 ± 116.4 mm3; n = 4-6 animals/treatment; P < 0.05), indicating earlier sexual maturation. At adulthood, these females and those exposed to ghrelin showed a tendency to higher percentages of embryo loss and/or foetal atrophy. In conclusion, ghrelin participates in reproductive foetal programming: Alterations in ghrelin activity during pregnancy modified body weight increase and anticipated puberty onset, exerting (or tending to) negative effects on adult reproductive function.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BioScientifica  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
GHRELIN  
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(D-Lys 3)GHRP-6  
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FETAL PROGRAMMING  
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REPRODUCTIVE PROGRAMMING  
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Biología Reproductiva  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
The role of intragestational ghrelin on postnatal development and reproductive programming in mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-22T16:44:09Z  
dc.journal.volume
156  
dc.journal.number
4  
dc.journal.pagination
331-351  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Bristol  
dc.description.fil
Fil: Torres, Pedro Javier. Universidad Nacional de Córdoba. Secretaria de Ciencia y Tecnología; Argentina  
dc.description.fil
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina  
dc.description.fil
Fil: Ponzio, Marina Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina  
dc.description.fil
Fil: Cantarelli, Verónica Inés. Ministerio de Ciencia, Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica. Fondo para la Investigación Científica y Tecnológica; Argentina  
dc.description.fil
Fil: Diez, Marcela. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Figueroa, S.. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina  
dc.description.fil
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina  
dc.journal.title
Reproduction  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1530/REP-18-0192  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/rep.bioscientifica.com/view/journals/rep/156/4/REP-18-0192.xml