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dc.contributor.author
Azcona, Pamela Liliana
dc.contributor.author
Montiel Schneider, María Gabriela
dc.contributor.author
Grunhut, Marcos
dc.contributor.author
Lassalle, Verónica Leticia
dc.date.available
2019-12-05T14:22:47Z
dc.date.issued
2018-12-18
dc.identifier.citation
Azcona, Pamela Liliana; Montiel Schneider, María Gabriela; Grunhut, Marcos; Lassalle, Verónica Leticia; Stimuli-responsive nanotheranostics intended for oncological diseases: In vitro evaluation of their target, diagnostic and drug release capabilities.; Royal Society of Chemistry; New Journal of Chemistry; 43; 5; 18-12-2018; 2126-2133
dc.identifier.issn
1144-0546
dc.identifier.uri
http://hdl.handle.net/11336/91478
dc.description.abstract
Magnetic nanotheranostics were designed from iron oxide nanoparticles functionalized with folic acid (FA) and loaded with doxorubicin (Doxo) as a therapeutic agent. The incorporation of Doxo was carefully examined to attain a satisfactory drug loading efficiency. The magnet-guiding ability was examined in vitro. To achieve this, a novel continuous flow system was fabricated to quantify the amount of MNPs retained in the magnet site in an environment and under conditions mimicking the bloodstream. The obtained data suggest that almost 21% of the total circulating nanoparticles accumulated in the target site after 45 min of assay. Such amount ensured the doses of Doxo commonly employed during in vivo studies. The release of Doxo was analysed by implementing an original procedure devoted to simulate the pathways followed by MNPs once intravenously administered. From these studies, reliable data on the amount of drug that effectively reached the target site were obtained. The efficiency of the nanosystems as selective contrast agents in MRI was analysed using clinical 1.5 T equipment. Their potential as T2 weighted contrast media was demonstrated. The data collected within this work appear as the former initial stage to validate the nanotheranostics before in vivo evaluation of this novel technology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MAGNETIC NANOPARTICLES
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NANOTHERANOSTICS
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FOLIC ACID
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DOXORUBICIN
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Nano-procesamiento
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Stimuli-responsive nanotheranostics intended for oncological diseases: In vitro evaluation of their target, diagnostic and drug release capabilities.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T21:31:45Z
dc.journal.volume
43
dc.journal.number
5
dc.journal.pagination
2126-2133
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Azcona, Pamela Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Montiel Schneider, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
New Journal of Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/nj/c8nj05289a#!divAbstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c8nj05289a
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