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dc.contributor.author
Sartuqui, Javier
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dc.contributor.author
Gardin, C.
dc.contributor.author
Ferroni, L.
dc.contributor.author
Zavan, B.
dc.contributor.author
Messina, Paula Verónica
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dc.date.available
2019-12-04T18:36:59Z
dc.date.issued
2018-05-26
dc.identifier.citation
Sartuqui, Javier; Gardin, C.; Ferroni, L.; Zavan, B.; Messina, Paula Verónica; Nanostructured hydroxyapatite networks: Synergy of physical and chemical cues to induce an osteogenic fate in an additive-free medium; Elsevier; Materials Today Communications; 16; 26-5-2018; 152-163
dc.identifier.issn
2352-4928
dc.identifier.uri
http://hdl.handle.net/11336/91389
dc.description.abstract
Nanoscale topography plays a central role in adult-stem-cell-niches. In this study we have demonstrated that by an accurate material design, mimicking the composition and structure of bone extracellular matrix, it is possible to guide human adipose stem cells (hASCs) to attain an osteogenic commitment, in vitro, without the requirement of soluble additives or grow factors. Alkaline Phosphatase (ALP) activity and Alizarin Red S test demonstrated that hASCs cultured onto hydroxyapatite frameworks dry-coating differentiated into mature osteoblasts even in the absence of specific inducing factors. Optical and electron scanning microscopic (SEM) observations revealed a direct cellular-material interaction that indicated an appropriate communication between nanotopographical features and the integrin receptors in the cell´s focal adhesions. Real-time quantitative PCR (RT-qPCR) analysis confirmed the expression of specific markers of pre-osteoblast and mature osteoblast stages as osterix (OSX), osteopontin (OPN), osteocalcin (OC) and; specific markers of extracellular matrix maturation and mineralization stages as alkaline phosphatase (ALPL), collagen type I alpha 1 (COL1A1) and osteonectin (ON). Osteoprotegerin (OPG), ALPL, COL1A1, and sclerostin (SOST) expressions were up regulated compared to osteogenic differentiation media conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADDITIVE FREE MEDIUM
dc.subject
ADIPOSE DERIVED STEM CELLS
dc.subject
HYDROXYAPATITE NETWORKS
dc.subject
OSTEOGENIC DIFFERENTIATION
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Nanostructured hydroxyapatite networks: Synergy of physical and chemical cues to induce an osteogenic fate in an additive-free medium
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T21:35:19Z
dc.journal.volume
16
dc.journal.pagination
152-163
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Sartuqui, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Gardin, C.. Università di Padova; Italia
dc.description.fil
Fil: Ferroni, L.. Università di Padova; Italia
dc.description.fil
Fil: Zavan, B.. Università di Padova; Italia
dc.description.fil
Fil: Messina, Paula Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Materials Today Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2352492818300631
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mtcomm.2018.05.010
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