Artículo
Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
Fecha de publicación:
09/2018
Editorial:
Wiley VCH Verlag
Revista:
Annalen Der Physik
ISSN:
0003-3804
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The dielectric response of bulk water follows laws of continuum electrostatics,a scheme often extrapolated without justification to treat confined interfacialwater, where the Debye polarization ansatz breaks down and discrete effectsmatter. Reconciling the discrete behavior with the continuum equationsrequires a conceptual leap, all the more so when assessing the electrostaticimpact of exclusion of individual water molecules. This work takes up thechallenge and identifies the nanoscale stickiness of a preformedwater-embedded hydrogen bond as phenomena not encompassed bycontinuum laws but quantitatively predictable when adopting a nanoscaletheory of dielectric response holding down to molecular dimensions.Nanoscale stickiness is known to drive basic cellular events and has beenmeasured using a molecular force probe but its physical underpinnings andcomputation have been lacking so far. The findings reported may impactmolecular design in bio-nanotechnology and shed light on standingchallenges in biophysics, especially on the protein folding problem, whereorganized compaction of the protein chain following nucleatingintramolecular hydrogen bonding demands explanation.
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Articulos(INQUISUR)
Articulos de INST.DE QUIMICA DEL SUR
Articulos de INST.DE QUIMICA DEL SUR
Citación
Fernandez, Ariel; Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018); Wiley VCH Verlag; Annalen Der Physik; 530; 9; 9-2018; 1800162(1-4)
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