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dc.contributor.author
Volpe, Verónica
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dc.contributor.author
Silva Do Nascimento, Danielle
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dc.contributor.author
Insausti, Matías
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dc.contributor.author
Grunhut, Marcos
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dc.date.available
2019-12-04T16:04:23Z
dc.date.issued
2018-06-05
dc.identifier.citation
Volpe, Verónica; Silva Do Nascimento, Danielle; Insausti, Matías; Grunhut, Marcos; Octyl p-methoxycinnamate loaded microemulsion based on Ocimum basilicum essential oil. Characterization and analytical studies for potential cosmetic applications; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 546; 05-6-2018; 285-292
dc.identifier.issn
0927-7757
dc.identifier.uri
http://hdl.handle.net/11336/91350
dc.description.abstract
A O/W microemulsion based on biocompatible materials was designed for a potential topical use as UVB filter, antiinflamatory and mosquito repellent. Octyl-p-methoxy cinnamate (OMC) is one of the most widely used sunscreen compounds. Nevertheless, their efficiency as UV filter is affected by irradiation because a photolysis process occurs. Ocimum basilicum essential oil is utilized in traditional medicine and as repellent of insects, among others. Hence, the proposed O/W microemulsion consisted of 6.0% of Ocimum basilicum essential oil (oil phase), 23% of a 2:1 mixture of decaethylene glycol mono-dodecyl ether (surfactant) and ethanol (co-surfactant), and 71% of water. OMC was successfully loaded in the O/W microemulsion (1.5%). The loaded system presented a particle size of (12.60 ± 0.10) nm and a polydispersity index of 0.389 ± 0.042. A spherical morphology and droplet sizes in nanometric range were corroborated by transmission electronic microscopy. The higher photostability of OMC in the O/W microemulsion with respect to the free-OMC was demonstrated by calculating the photolysis kinetic constants (0.00186 s−1 and 0.00457 s−1, respectively) which were obtained through a photolysis study assisted by multivariate curve resolution-alternating least squares algorithm. Moreover, the stability of the system over time and under different conditions was demonstrated. On the other hand, a chromatographic analysis of the essential oil corroborated the presence of estragole (93.2%) which presents a documented antiinflammatory activity, and seven compounds with a well reported mosquito repellent activity, such as linalool (2.81%), cineole (0.57%), among others. On this form, the proposed O/W microemulsion presents optimal chemical and physicochemical characteristics for a potential application in cosmetic product.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIINFLAMMATORY ACTIVITY
dc.subject
ESSENTIAL OIL
dc.subject
MICROEMULSION
dc.subject
MOSQUITO REPELLENT
dc.subject
OCIMUM BASILICUM
dc.subject
OCTYL P-METHOXYCINNAMATE
dc.subject
PHOTOLYSIS STUDY
dc.subject.classification
Química Analítica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Octyl p-methoxycinnamate loaded microemulsion based on Ocimum basilicum essential oil. Characterization and analytical studies for potential cosmetic applications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:18:30Z
dc.journal.volume
546
dc.journal.pagination
285-292
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Volpe, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Silva Do Nascimento, Danielle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Insausti, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Colloids and Surfaces A: Physicochemical and Engineering Aspects
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775718301596
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfa.2018.02.070
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