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dc.contributor.author
Rossi, Soledad Paola  
dc.contributor.author
Walenta, Lena  
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Rey Ares, Veronica  
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Köhn, Frank-Michael  
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Ulrich Schwarzer, J.  
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Welter, Harald  
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Calandra, Ricardo Saul  
dc.contributor.author
Frungieri, Monica Beatriz  
dc.contributor.author
Mayerhofer, Artur  
dc.date.available
2019-12-01T16:19:54Z  
dc.date.issued
2018-10-15  
dc.identifier.citation
Rossi, Soledad Paola; Walenta, Lena; Rey Ares, Veronica; Köhn, Frank-Michael; Ulrich Schwarzer, J.; et al.; Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells; Elsevier Ireland; Molecular and Cellular Endocrinology; 474; 15-10-2018; 1-9  
dc.identifier.issn
0303-7207  
dc.identifier.uri
http://hdl.handle.net/11336/91072  
dc.description.abstract
Stress activates the sympathetic nervous system and is linked to impaired fertility in man. We hypothesized that catecholamines by acting on testicular cells have a role in these events, possibly by fostering an inflammatory environment. The cells of the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), express adrenergic receptors (ADRs) α1B, α1D, β1 and β2. A selective α1-ADR agonist, phenylephrine, increased intracellular Ca 2+ -levels in cultured HTPCs and induced COX-2, IL-6 and MCP-1 mRNA expression without affecting IL-1β mRNA. These changes were paralleled by a significant increase in the secretion of IL-6 and MCP-1. Epinephrine was also effective, but salbutamol, a selective β2-ADR agonist was not. Our results suggest that stress-associated elevation of catecholamines may be able to promote inflammatory events by targeting peritubular cells in the human testis. Blockage of α1-ADRs may therefore be a novel way to interfere with stress-related impairment of male reproductive functions.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ADRENERGIC RECEPTORS  
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EPINEPHRINE  
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INFERTILITY  
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INFLAMMATION  
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MALE FERTILITY  
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Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
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Biología Reproductiva  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-09-27T15:23:23Z  
dc.journal.volume
474  
dc.journal.pagination
1-9  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Shannon  
dc.description.fil
Fil: Rossi, Soledad Paola. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Walenta, Lena. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Rey Ares, Veronica. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Köhn, Frank-Michael. Andrologicum; Alemania  
dc.description.fil
Fil: Ulrich Schwarzer, J.. Andrology Center Munich; Alemania  
dc.description.fil
Fil: Welter, Harald. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania  
dc.journal.title
Molecular and Cellular Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0303720718300509?via%3Dihub  
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info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2018.01.027  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/29407194