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dc.contributor.author
Gallagher Jones, Marcus
dc.contributor.author
Glynn, Calina
dc.contributor.author
Boyer, David R.
dc.contributor.author
Martynowycz, Michael W.
dc.contributor.author
Hernandez, Evelyn
dc.contributor.author
Miao, Jennifer
dc.contributor.author
Zee, Chih Te
dc.contributor.author
Novikova, Irina V.
dc.contributor.author
Goldschmidt, Lukasz
dc.contributor.author
Mc Farlane, Heather T.
dc.contributor.author
Helguera, Gustavo Fernando
dc.contributor.author
Evans, James E.
dc.contributor.author
Sawaya, Michael R.
dc.contributor.author
Cascio, Duilio
dc.contributor.author
Eisenberg, David S.
dc.contributor.author
Gonen, Tamir
dc.contributor.author
Rodriguez, Jose A.
dc.date.available
2019-12-01T16:19:16Z
dc.date.issued
2018-02
dc.identifier.citation
Gallagher Jones, Marcus; Glynn, Calina; Boyer, David R.; Martynowycz, Michael W.; Hernandez, Evelyn; et al.; Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp; Nature Publishing Group; Nature Structural and Molecular Biology; 25; 2; 2-2018; 131-134
dc.identifier.issn
1545-9985
dc.identifier.uri
http://hdl.handle.net/11336/91071
dc.description.abstract
The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2–α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named ‘polar clasps’.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CRYO-EM
dc.subject
PRION
dc.subject
STRUCTURE
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T15:24:40Z
dc.journal.volume
25
dc.journal.number
2
dc.journal.pagination
131-134
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Gallagher Jones, Marcus. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Glynn, Calina. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Boyer, David R.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Martynowycz, Michael W.. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil
Fil: Hernandez, Evelyn. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Miao, Jennifer. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Zee, Chih Te. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Novikova, Irina V.. Pacific Northwest National Laboratory; Estados Unidos
dc.description.fil
Fil: Goldschmidt, Lukasz. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Mc Farlane, Heather T.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Helguera, Gustavo Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Evans, James E.. Pacific Northwest National Laboratory; Estados Unidos
dc.description.fil
Fil: Sawaya, Michael R.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Cascio, Duilio. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Eisenberg, David S.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Gonen, Tamir. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil
Fil: Rodriguez, Jose A.. University of California at Los Angeles; Estados Unidos
dc.journal.title
Nature Structural and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41594-017-0018-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41594-017-0018-0
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