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Artículo

Glycosylation-dependent galectin-receptor interactions promote Chlamydia trachomatis infection

Lujan, Agustin LeonardoIcon ; Croci Russo, Diego OmarIcon ; Gambarte Tudela, Julian AlbertoIcon ; Losinno, Antonella DeniseIcon ; Cagnoni, AlejandroIcon ; Mariño, Karina ValeriaIcon ; Damiani, María Teresa; Rabinovich, Gabriel AdriánIcon
Fecha de publicación: 26/06/2018
Editorial: National Academy of Sciences
Revista: Proceedings of the National Academy of Sciences of The United States of America
ISSN: 0027-8424
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología; Inmunología

Resumen

Chlamydia trachomatis (Ct) constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, Ct has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both bacterial and host glycans. Here, we show that galectin-1 (Gal1), an endogenous lectin widely expressed in female and male genital tracts, promotes Ct infection. Through glycosylation-dependent mechanisms involving recognition of bacterial glycoproteins and N-glycosylated host cell receptors, Gal1 enhanced Ct attachment to cervical epithelial cells. Exposure to Gal1, mainly in its dimeric form, facilitated bacterial entry and increased the number of infected cells by favoring Ct–Ct and Ct–host cell interactions. These effects were substantiated in vivo in mice lacking Gal1 or complex β1–6-branched N-glycans. Thus, disrupting Gal1–N-glycan interactions may limit the severity of chlamydial infection by inhibiting bacterial invasion of host cells.
Palabras clave: CHLAMYDIA TRACHOMATIS , GALECTIN-1 , GLYCOSYLATION , HOST–PATHOGEN INTERACTIONS , SEXUALLY TRANSMITTED DISEASES
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/91057
URL: https://www.pnas.org/content/115/26/E6000.long
DOI: http://dx.doi.org/10.1073/pnas.1802188115
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Lujan, Agustin Leonardo; Croci Russo, Diego Omar; Gambarte Tudela, Julian Alberto; Losinno, Antonella Denise; Cagnoni, Alejandro; et al.; Glycosylation-dependent galectin-receptor interactions promote Chlamydia trachomatis infection; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 115; 26; 26-6-2018; E6000-E6009
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