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dc.contributor.author
Kosik, Ivan
dc.contributor.author
Ince, William L.
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Gentles, Lauren E.
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Oler, Andrew J.
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Kosikova, Martina
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Angel, Matthew
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Magadan, Javier Guillermo
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Xie, Hang
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Brooke, Christopher B.
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Yewdell, Jonathan W.
dc.date.available
2019-11-29T21:00:01Z
dc.date.issued
2018-01
dc.identifier.citation
Kosik, Ivan; Ince, William L.; Gentles, Lauren E.; Oler, Andrew J.; Kosikova, Martina; et al.; Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs; Public Library of Science; Plos Pathogens; 14; 1; 1-2018; 1-19; e1006796
dc.identifier.issn
1553-7366
dc.identifier.uri
http://hdl.handle.net/11336/91035
dc.description.abstract
Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for designing durable vaccines and therapeutics. Here, we utilize the primerID method of error-correcting viral population sequencing to reveal an unexpected role for hemagglutinin (HA) glycosylation in compensating for fitness defects resulting from escape from anti-HA neutralizing antibodies. Antibody-free propagation following antigenic escape rapidly selected viruses with mutations that modulated receptor binding avidity through the addition of N-linked glycans to the HA globular domain. These findings expand our understanding of the viral mechanisms that maintain fitness during antigenic evolution to include glycan addition, and highlight the immense power of high-definition virus population sequencing to reveal novel viral adaptive mechanisms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INFLUENZA
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HEMAGGLUTININ
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ANTIBODY ESCAPE
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VIRAL EVOLUTION
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Virología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:07:16Z
dc.journal.volume
14
dc.journal.number
1
dc.journal.pagination
1-19; e1006796
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Kosik, Ivan. National Institute of Allergy and Infectious Diseases; Estados Unidos
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Fil: Ince, William L.. National Institute of Allergy and Infectious Diseases; Estados Unidos. National Center For Toxicological Research. Food And Drug Administration; Estados Unidos
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Fil: Gentles, Lauren E.. National Institute of Allergy and Infectious Diseases; Estados Unidos
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Fil: Oler, Andrew J.. National Institute of Allergy and Infectious Diseases; Estados Unidos
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Fil: Kosikova, Martina. National Center For Toxicological Research. Food And Drug Administration; Estados Unidos
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Fil: Angel, Matthew. National Institute of Allergy and Infectious Diseases; Estados Unidos
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Fil: Magadan, Javier Guillermo. National Institute of Allergy and Infectious Diseases; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
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Fil: Xie, Hang. National Center For Toxicological Research. Food And Drug Administration; Estados Unidos
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Fil: Brooke, Christopher B.. University of Illinois at Urbana; Estados Unidos
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Fil: Yewdell, Jonathan W.. National Institute of Allergy and Infectious Diseases; Estados Unidos
dc.journal.title
Plos Pathogens
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.ppat.1006796
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006796
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