Artículo
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides
Fecha de publicación:
12/2003
Editorial:
Bentham Science Publishers
Revista:
Mini-reviews In Medicinal Chemistry
ISSN:
1389-5575
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated.
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Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Rodriguez, Juan Bautista; Comin, Maria Julieta; New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 3; 2; 12-2003; 95-114
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