Artículo
Metal Enhanced fluorescence emission and Quenching protection effect with a host-guest Nanophotonic-supramolecular structure
Fecha de publicación:
07/2018
Editorial:
Society of Photo-Optical Instrumentation Engineers
Revista:
Journal Of Nanophotonics
e-ISSN:
1934-2608
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The functionalization of the nanoparticle's (NP) surface is one method for tuning their overall properties to fit targeted applications. We developed a nanosensor based on the specific supramolecular interactions between β-cyclodextrin (βCD) nanocavities and organic molecules of biological interests using the metal-enhanced fluorescence effect (MEF) as the detection signal. We grafted βCD, a typical macrocyclic host molecule that interacts specifically with different organic molecules and changes their physical properties (such as their fluorescence emission intensity), on gold NPs. To evaluate this nanosensor and the effect of the metallic core, we worked with a typical organic molecule, Rhodamine B (RhB), that has a strong association constant with βCD (5700 M-1) and is well-known to be quenched in the presence of cyclodextrins (CDs). The results show that, by grafting βCD on gold NPs, it is possible to increase the sensitivity of RhB detection by 70%, 80%, and 294% when compared with solutions in (1) a phosphate buffer, (2) with βCD, and (3) with Au NPs, respectively. These results show that the use of a supramolecular system attached to a metallic NP can interact specifically with a dye to enhance its fluorescence emission through the MEF effect. Moreover, this type of nanosystem can overcome the quenching of the signal by the matrix, such in the case of RhB with CDs. Eventually, this concept could be extended to other dyes with different quenching effects. For this reason, this type of nanosensor system could be used in the future to protect and enhance the dye emission of fluorophores in different biological media.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Veglia, Alicia Viviana; Bracamonte, Angel Guillermo; Metal Enhanced fluorescence emission and Quenching protection effect with a host-guest Nanophotonic-supramolecular structure; Society of Photo-Optical Instrumentation Engineers; Journal Of Nanophotonics; 12; 3; 7-2018
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