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dc.contributor.author
Villena, Julio Cesar
dc.contributor.author
Barbieri, Natalia Paola del Carmen
dc.contributor.author
Salva, Maria Susana
dc.contributor.author
Herrera, Héctor Matías
dc.contributor.author
Alvarez, Gladis Susana
dc.date.available
2019-11-29T13:08:27Z
dc.date.issued
2009-07
dc.identifier.citation
Villena, Julio Cesar; Barbieri, Natalia Paola del Carmen; Salva, Maria Susana; Herrera, Héctor Matías; Alvarez, Gladis Susana; Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat killed Lactobacillus casei; Wiley Blackwell Publishing, Inc; Microbiology And Immunology; 53; 11; 7-2009; 636-646
dc.identifier.issn
0385-5600
dc.identifier.uri
http://hdl.handle.net/11336/90869
dc.description.abstract
The present study analyzed whether nasal administration of viable and non-viable Lactobacillus casei CRL 431 to immunocompromised mice was capable of increasing resistance against Streptococcus pneumoniae. Weaned mice were malnourished after consuming a PFD for 21 days.Malnourished mice were fed a BCD for 7 days or BCD for 7 days with viable or non-viable L. casei nasal treatments on day 6 and day7 (BCD+LcV and BCD+LcN, respectively). The MNC group received PFD whereas the WNC mice consumed BCD. MNC mice showed greater lung colonization, more severe lung injuries, impaired leukocyte recruitment and reduced antibodies and cytokine production when compared with WNC mice. Administration of L. casei increased the resistance of malnourished mice to the infection. Both BCD+LcV and BCD+LcN treatments prevented the dissemination of the pathogen to the blood andinduced its lung clearance. BCD+LcV or BCD+LcN groups showed improved production of TNF-alfa and activity of phagocytes in the respiratory tract, an effect that was not observed in the BCD control group. In addition, IL-4 and IL-10 were significantly increased in BCD+LcV and BCD+LcN groups, which correlated with the increase in the levels of specific respiratory IgA. The nasal treatments with L. casei were also effective at stimulating the production of specific IgG at both the systemic and the respiratory levels. The comparative study between the viable and the non-viable bacteria demonstrated that viability would be an important factor to achieve maximum protective effects.However, the results from this study suggest that heat-killed lactic acid bacteria are also effective in the immunomodulation of the systemic and respiratory immune system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IMMUNOMODULATION
dc.subject
LACTOBACILLUS CASEI
dc.subject
MALNUTRITION
dc.subject
PNEUMOCOCCAL INFECTION
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat killed Lactobacillus casei
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-25T18:18:24Z
dc.journal.volume
53
dc.journal.number
11
dc.journal.pagination
636-646
dc.journal.pais
Australia
dc.journal.ciudad
Melbourne
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Barbieri, Natalia Paola del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Herrera, Héctor Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.journal.title
Microbiology And Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/j.1348-0421.2009.00171.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1348-0421.2009.00171.x


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