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dc.contributor.author
Holubiec, Mariana Ines  
dc.contributor.author
Romero, Juan Ignacio  
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Suárez, Juan  
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Portavella, Manuel  
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Fernández Espejo, Emilio  
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Blanco, Eduardo  
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Galeano, Pablo  
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Rodríguez de Fonseca, Fernando  
dc.date.available
2019-11-28T21:23:03Z  
dc.date.issued
2018-10  
dc.identifier.citation
Holubiec, Mariana Ines; Romero, Juan Ignacio; Suárez, Juan; Portavella, Manuel; Fernández Espejo, Emilio; et al.; Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia; Springer; Psychopharmacology; 235; 10; 10-2018; 2929-2945  
dc.identifier.issn
0033-3158  
dc.identifier.uri
http://hdl.handle.net/11336/90843  
dc.description.abstract
Rational: Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are acylethanolamides that do not bind to CB1 or CB2 receptors and thus they do not present cannabinoid activity. These molecules are agonist compounds of peroxisome proliferator-activator receptor alpha (PPARα), which modulates the expression of different genes that are related to glucose and lipid metabolism, inflammation, differentiation and proliferation. Objective: In the present study, we analyzed the effects that the administration of PEA or OEA, after a neonatal AI event, has over different areas of the hippocampus. Methods: To this end, 7-day-old rats were subjected to AI and then treated with vehicle, OEA (2 or 10 mg/kg) or PEA (2 or 10 mg/kg). At 30 days of age, animals were subjected to behavioral tests followed by immunohistochemical studies. Results: Results showed that neonatal AI was associated with decreased locomotion, as well as recognition and spatial memory impairments. Furthermore, these deficits were accompanied with enhanced neuroinflammation and astrogliosis, as well as a decreased PPARα expression. PEA treatment was able to prevent neuroinflammation, reduce astrogliosis and preserve cognitive functions. Conclusions: These results indicate that the acylethanolamide PEA may play an important role in the mechanisms underlying neonatal AI, and it could be a good candidate for further studies regarding neonatal AI treatments.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ASTROGLIOSIS  
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MEMORY IMPAIRMENT  
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NEONATAL ANOXIA-ISCHEMIA  
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NEUROINFLAMMATION  
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OLEOYLETHANOLAMIDE  
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PALMITOYLETHANOLAMIDE  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-22T17:42:44Z  
dc.identifier.eissn
1432-2072  
dc.journal.volume
235  
dc.journal.number
10  
dc.journal.pagination
2929-2945  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Hospital Regional Universitario de Málaga; España  
dc.description.fil
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Hospital Regional Universitario de Málaga; España  
dc.description.fil
Fil: Suárez, Juan. Hospital Regional Universitario de Málaga; España  
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Fil: Portavella, Manuel. Universidad de Sevilla; España  
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Fil: Fernández Espejo, Emilio. Universidad de Sevilla; España  
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Fil: Blanco, Eduardo. Universidad de Lleida. Instituto de Recerca Biomédica; España  
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Fil: Galeano, Pablo. Hospital Regional Universitario de Málaga; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Rodríguez de Fonseca, Fernando. Hospital Regional Universitario de Málaga; España  
dc.journal.title
Psychopharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00213-018-4982-9  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00213-018-4982-9