Artículo
Microwave-assisted conditions for the green synthesis of thioacetamide. Optimization of reaction parameters using response surface methodology
Dominguez, Rodrigo Ezequiel
; Pfaffen, Maria Valeria del Valle
; Argüello, Gustavo Alejandro
; Iriarte, Ana Graciela
Fecha de publicación:
09/2018
Editorial:
Elsevier B.V.
Revista:
Sustainable Chemistry and Pharmacy
ISSN:
2352-5541
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An optimized method for the synthesis of thioacetamide (TA) in relation to the consumption of materials and energy, which reduces the production of waste and minimizes costs, is hitherto presented. The most important highlight of this work is the use of an inexpensive and readily accessible reactant for the thionation process (i.e. phosphorus pentasulfide, P4S10), combined with both alumina as solid support and a non-conventional microwave (MW) irradiation technique. In addition to this, Response Surface Methodology (RSM) was used to optimize the entire procedure of the synthesis for simultaneous tripled-maximization of Yield (ε), Mass Intensity (MI) and Mass Productivity (MP). Acetamide (AC)/P4S10 molar ratio, time and temperature of reaction were chosen as independent variables; while ε MI and MP were chosen as responses. The determination of these green metrics parameters allow to evaluate the sustainability of the reaction and compare with other methodologies. A quadratic regression model was derived with satisfactory prediction. Tripled optimization with desirability function predicts a maximum ε of 100%, maximum MI of 29.00 kg/kg and a maximum MP of 3.45% under the following experimental conditions: AC/P4S10 molar ratio of 2.10, time of irradiation of 14 min and a temperature 140 °C.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Dominguez, Rodrigo Ezequiel; Pfaffen, Maria Valeria del Valle; Argüello, Gustavo Alejandro; Iriarte, Ana Graciela; Microwave-assisted conditions for the green synthesis of thioacetamide. Optimization of reaction parameters using response surface methodology; Elsevier B.V.; Sustainable Chemistry and Pharmacy; 9; 9-2018; 51-62
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