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dc.contributor.author
Quinn, Brettni
dc.contributor.author
Rodman, Nyah
dc.contributor.author
Jara, Eugenio
dc.contributor.author
Fernandez, Jennifer S.
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Martinez, Jasmine
dc.contributor.author
Traglia, German Matias
dc.contributor.author
Montaña, Sabrina Daiana
dc.contributor.author
Cantera, Virginia
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Place, Kori
dc.contributor.author
Bonomo, Robert A.
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Iriante, Andrés
dc.contributor.author
Ramirez, María Soledad
dc.date.available
2019-11-27T19:11:07Z
dc.date.issued
2018-12
dc.identifier.citation
Quinn, Brettni; Rodman, Nyah; Jara, Eugenio; Fernandez, Jennifer S.; Martinez, Jasmine; et al.; Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-16
dc.identifier.uri
http://hdl.handle.net/11336/90692
dc.description.abstract
In the past few decades Acinetobacter baumannii has emerged as a notorious nosocomial pathogen because of its ability to acquire genetic material and persist in extreme environments. Recently, human serum albumin (HSA) was shown to significantly increase natural transformation frequency in A. baumannii. This observation led us to perform transcriptomic analysis of strain A118 under HSA induction to identify genes that are altered by HSA. Our results revealed the statistically significant differential expression of 296 protein-coding genes, including those associated with motility, biofilm formation, metabolism, efflux pumps, capsule synthesis, and transcriptional regulation. Phenotypic analysis of these traits showed an increase in surface-associated motility, a decrease in biofilm formation, reduced activity of a citric acid cycle associated enzyme, and increased survival associated with zinc availability. Furthermore, the expression of genes known to play a role in pathogenicity and antibiotic resistance were altered. These genes included those associated with RND-type efflux pumps, the type VI secretion system, iron acquisition/metabolism, and ß-lactam resistance. Together, these results illustrate how human products, in particular HSA, may play a significant role in both survival and persistence of A. baumannii.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HSA
dc.subject
Acinetobacter baumannii
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T15:00:00Z
dc.identifier.eissn
2045-2322
dc.journal.volume
8
dc.journal.number
1
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Quinn, Brettni. California State University; Estados Unidos
dc.description.fil
Fil: Rodman, Nyah. California State University; Estados Unidos
dc.description.fil
Fil: Jara, Eugenio. Universidad de la República; Uruguay
dc.description.fil
Fil: Fernandez, Jennifer S.. California State University; Estados Unidos
dc.description.fil
Fil: Martinez, Jasmine. California State University; Estados Unidos
dc.description.fil
Fil: Traglia, German Matias. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Montaña, Sabrina Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Cantera, Virginia. Universidad de la República; Uruguay
dc.description.fil
Fil: Place, Kori. California State University; Estados Unidos
dc.description.fil
Fil: Bonomo, Robert A.. Case Western Reserve University; Estados Unidos. Louis Stokes Cleveland Department of Veterans Affair; Estados Unidos
dc.description.fil
Fil: Iriante, Andrés. Universidad de la República; Uruguay
dc.description.fil
Fil: Ramirez, María Soledad. California State University; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-018-33072-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-33072-z
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