Artículo
Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease
Martín Giménez, Virna Margarita
; Noriega, Sandra; Kassuha, Diego Enrique
; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando
Fecha de publicación:
07/2018
Editorial:
SAGE Publications
Revista:
Therapeutic Advances in Cardiovascular Disease
ISSN:
1753-9455
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.
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Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Martín Giménez, Virna Margarita; Noriega, Sandra; Kassuha, Diego Enrique; Fuentes, Lucia Beatriz; Manucha, Walter Ariel Fernando; Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease; SAGE Publications; Therapeutic Advances in Cardiovascular Disease; 12; 7; 7-2018; 177-190
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