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Artículo

Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control

Gorojod, Roxana MayraIcon ; Alaimo, AgustinaIcon ; Porte Alcon, SoledadIcon ; Martinez, Jimena HebeIcon ; Cortina, María EugeniaIcon ; Vazquez, Elba SusanaIcon ; Kotler ML (*) BOTH AUTHORS CONTRIBUTED EQUALLY TO THIS WORK
Fecha de publicación: 10/2018
Editorial: Elsevier Ireland
Revista: Toxicology Letters
ISSN: 0378-4274
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways. In Parkinson disease patients, elevated HO-1 expression levels in astrocytes are involved in antioxidant defense. In the present work, employing an in vitro model of Mn2+-induced Parkinsonism in astroglial C6 cells, we investigated the role of HO-1 in both apoptosis and mitochondrial quality control (MQC). HO-1 exerted a protective effect against Mn2+ injury. In fact, HO-1 decreased both intracellular and mitochondrial reactive oxygen species as well as the appearance of apoptotic features. Considering that Mn2+ induces mitochondrial damage and a defective MQC has been implicated in neurodegenerative diseases, we hypothesized that HO-1 could mediate cytoprotection by regulating the MQC processes. Results obtained provide the first evidence that the beneficial effects of HO-1 in astroglial cells are mediated by the maintenance of both mitochondrial fusion/fission and biogenesis/mitophagy balances. Altogether, our data demonstrate a pro-survival function for HO-1 in Mn2+-induced apoptosis that involves the preservation of a proper MQC. These findings point to HO-1 as a new therapeutic target linked to mitochondrial pathophysiology in Manganism and probably Parkinson´s disease.
Palabras clave: ASTROGLIA , HEME OXYGENASE-1 , MANGANESE , MANGANISM , MITOCHONDRIAL QUALITY CONTROL , OXIDATIVE STRESS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/90602
URL: https://www.sciencedirect.com/science/article/pii/S0378427418315327
DOI: https://doi.org/10.1016/j.toxlet.2018.07.045
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Gorojod, Roxana Mayra; Alaimo, Agustina; Porte Alcon, Soledad; Martinez, Jimena Hebe; Cortina, María Eugenia; et al.; Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control; Elsevier Ireland; Toxicology Letters; 295; 10-2018; 357-368
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