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Artículo

Mitochondrial peroxynitrite generation is mainly driven by superoxide steady-state concentration rather than by nitric oxide steady-state concentration

Valdez, Laura BatrizIcon ; Bombicino, Silvina SoniaIcon ; Iglesias, Dario EzequielIcon ; Rukavina Mikusic, Ivana Agustina; Boveris, Alberto AntonioIcon
Fecha de publicación: 03/2018
Editorial: MedCrave Group
Revista: International Journal of Molecular Biology
ISSN: 2573-2889
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular; Biofísica

Resumen

In biological systems, ONOO- production depends on production rates of NO and O2-, and on the reactions of these two free radicals with other biological components, which limit the local concentrations of NO and O2-. In mitochondria, O2- is generated through the autoxidation of semiquinones at Complexes I and III, and it may suffer the SOD-catalysed dismutation reaction to produce H2O2 or react with NO in a classical termination reaction between free radicals. These diffusion-controlled reactions kinetically compete for O2- degradation. Results from our laboratory have shown that even in physiopathological situations in which NO production is reduced, such as the mitochondrial dysfunction associated to stunned heart, mitochondrial ONOO- production rate may be slightly increased if the steady-state concentration of O2- is augmented. The enhancement in O2- concentration leads to an increase in its degradation by reaction with NO, decreasing NO bioavailability and increasing ONOO- production rate. Therefore, mitochondrial ONOO- generation is mainly driven by O2- rather than by NO steady-state concentrations. In this scenario, the switch from signalling pathways of NO to oxidative damage takes place and oxidation reactions of biomolecules or modification of proteins by nitration may occur.
Palabras clave: MITOCHONDRIA , PEROXINITRITE , NITRIC OXIDE , SUPEROXIDE , STEADY-STATES
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/90570
URL: https://medcraveonline.com/IJMBOA/mitochondrial-peroxynitrite-generation-is-main
DOI: https://doi.org/10.15406/ijmboa.2018.03.00051
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Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Valdez, Laura Batriz; Bombicino, Silvina Sonia; Iglesias, Dario Ezequiel; Rukavina Mikusic, Ivana Agustina; Boveris, Alberto Antonio; Mitochondrial peroxynitrite generation is mainly driven by superoxide steady-state concentration rather than by nitric oxide steady-state concentration ; MedCrave Group; International Journal of Molecular Biology; 3; 2; 3-2018; 58-63
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