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dc.contributor.author
Garramuño, Patricia
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dc.contributor.author
Battle, Daniel
dc.date.available
2019-11-26T19:37:40Z
dc.date.issued
2018-07
dc.identifier.citation
Garramuño, Patricia; Battle, Daniel; Hypokalemic Distal Renal Tubular Acidosis; W B Saunders Co-Elsevier Inc; Advances In Chronic Kidney Disease; 25; 4; 7-2018; 303-320
dc.identifier.issn
1548-5595
dc.identifier.uri
http://hdl.handle.net/11336/90553
dc.description.abstract
Distal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic acidosis with impaired urinary acid excretion in the presence of a normal or moderately reduced glomerular filtration rate. Failure in urinary acid excretion results from reduced H+ secretion by intercalated cells in the distal nephron. This results in decreased excretion of NH4 + and other acids collectively referred as titratable acids while urine pH is typically above 5.5 in the face of systemic acidosis. The clinical phenotype in patients with DRTA is characterized by stunted growth with bone abnormalities in children as well as nephrocalcinosis and nephrolithiasis that develop as the consequence of hypercalciuria, hypocitraturia, and relatively alkaline urine. Hypokalemia is a striking finding that accounts for muscle weakness and requires continued treatment together with alkali-based therapies. This review will focus on the mechanisms responsible for impaired acid excretion and urinary potassium wastage, the clinical features, and diagnostic approaches of hypokalemic DRTA, both inherited and acquired.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
W B Saunders Co-Elsevier Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACID EXCRETION
dc.subject
DISTAL RTA
dc.subject
GROWTH FAILURE
dc.subject
HYPERCHLOREMIC METABOLIC ACIDOSIS
dc.subject
HYPOKALEMIA
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hypokalemic Distal Renal Tubular Acidosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:08:27Z
dc.journal.volume
25
dc.journal.number
4
dc.journal.pagination
303-320
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Garramuño, Patricia. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Battle, Daniel. Northwestern University; Estados Unidos
dc.journal.title
Advances In Chronic Kidney Disease
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1053/j.ackd.2018.05.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1548559518300995
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