Artículo
Effects of quercetin on heart nitric oxide metabolism in L-NAME treated rats
Calabró López, María Valeria
; Litterio, Maria Corina
; Fraga, César Guillermo
; Galleano, Mónica Liliana
; Piotrkowski, Barbara
Fecha de publicación:
06/2018
Editorial:
Elsevier Science Inc
Revista:
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study investigated the effects of a quercetin-supplemented diet on the biochemical changes installed in the heart of NO-deficient rats in terms of oxidants production and NO bioavailability determinants. Sprague-Dawley rats were subjected to Nω-nitro-L-arginine methyl ester (L-NAME) treatment (360 mg/L L-NAME in the drinking water, 4 d) with or without supplementation with quercetin (4 g/kg diet). L-NAME administration led to increased blood pressure (BP) (30%), decreased nitric oxide synthase (NOS) activity (50%), and increases in NADPH oxidase (NOX)-dependent superoxide anion production (60%) and p47phox protein level (65%). The co-administration of quercetin prevented the increase in BP and the activation of NOX but did not modify the decrease in NOS activity caused by L-NAME. In addition, quercetin affected oxidative stress parameters as glutathione oxidation, and the activities of oxidant detoxifying enzymes superoxide dismutase, glutathione peroxidase, and catalase. Thus, quercetin administration counteracts L-NAME effects on NO bioavailability determinants in vivo, essentially through controlling NOX-mediated superoxide anion production.
Palabras clave:
BIOACTIVES
,
CARDIOVASCULAR
,
FLAVONOID
,
HYPERTENSION
,
OXYGEN RADICALS
,
POLYPHENOLS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Calabró López, María Valeria; Litterio, Maria Corina; Fraga, César Guillermo; Galleano, Mónica Liliana; Piotrkowski, Barbara; Effects of quercetin on heart nitric oxide metabolism in L-NAME treated rats; Elsevier Science Inc; Archives of Biochemistry and Biophysics; 647; 6-2018; 47-53
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