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Artículo

Immunization with Larrea divaricata Cav. proteins elicits opsonic antibodies against Pseudomonas aeruginosa and induces phagocytic activity of murine macrophages

Canale, Fernando PabloIcon ; Dávila, Silvia del Valle; Sasso, Corina VerónicaIcon ; Pellarin, Nicolas Wilson; Mattar Domínguez, María Aída
Fecha de publicación: 05/2018
Editorial: Academic Press Ltd - Elsevier Science Ltd
Revista: Microbial Pathogenesis
ISSN: 0882-4010
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Pseudomonas aeruginosa is an opportunistic pathogen implicated in nosocomial infections for which no vaccines have been approved. Larrea divaricata Cav. (Jarilla) is a widely spread plant in America and it is used in folk medicine to treat several pathologies. It has also been shown that antibodies elicited against Jarilla proteins of crude extract (JPCE) cross-react with proteins from gram-negative bacteria. In this study we aim to assess the contribution of anti-JPCE antibodies in the opsonophagocytosis of P. aeruginosa by murine macrophages. Levels of reactivity of anti-JPCE IgG and IgA antibodies against cell and membrane proteins suggest that these proteins induce a response that could favor opsonic bacterial recognition, which is important for the elimination of bacteria on mucous membranes, useful in the early stages of infection. Opsonophagocytosis assays also show that these antibodies could favor bacteria intake. These results together with previous observations that indicate that anti-JPCE antibodies are able to neutralize P. aeruginosa enzymes point L. divaricata proteins as candidates for vaccine development.
Palabras clave: AQUEOUS EXTRACT , CROSS-REACTION , IMMUNOGENIC PROTEINS , LARREA DIVARICATA , OPSONOPHAGOCYTOSIS , PSEUDOMONAS AERUGINOSA
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/90373
DOI: https://doi.org/10.1016/j.micpath.2018.03.029
URL: https://www.sciencedirect.com/science/article/pii/S0882401017314444
Colecciones
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Canale, Fernando Pablo; Dávila, Silvia del Valle; Sasso, Corina Verónica; Pellarin, Nicolas Wilson; Mattar Domínguez, María Aída; Immunization with Larrea divaricata Cav. proteins elicits opsonic antibodies against Pseudomonas aeruginosa and induces phagocytic activity of murine macrophages; Academic Press Ltd - Elsevier Science Ltd; Microbial Pathogenesis; 118; 5-2018; 257-267
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