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dc.contributor.author
Schroyens, Natalie
dc.contributor.author
Bender, Crhistian Luis
dc.contributor.author
Alfei Palloni, Joaquin Matías
dc.contributor.author
Molina, Víctor Alejandro
dc.contributor.author
Luyten, Laura
dc.contributor.author
Beckers, Tom
dc.date.available
2019-11-25T13:35:57Z
dc.date.issued
2018-11
dc.identifier.citation
Schroyens, Natalie; Bender, Crhistian Luis; Alfei Palloni, Joaquin Matías; Molina, Víctor Alejandro; Luyten, Laura; et al.; Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats; Elsevier Science; Behavioural Brain Research; 359; 11-2018; 172-180
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/89649
dc.description.abstract
The present study aimed to investigate the influence of housing conditions on contextual fear memory malleability. Male Wistar rats were housed in enriched, standard, or impoverished conditions after weaning and remained in these conditions throughout the entire experiment. After six weeks into those housing conditions, all animals underwent a 3-day protocol including contextual fear conditioning (day 1), memory reactivation followed by systemic administration of midazolam or vehicle (day 2), and a retention test (day 3). Percentage freezing was used as a behavioral measure of contextual fear. There was no evidence for an effect of housing conditions on the sensitivity of contextual fear memory to amnestic effects of post-reactivation midazolam administration, and no indication for amnestic effects of post-reactivation midazolam overall (including in the standard group). The inability to replicate previous demonstrations of post-reactivation amnesia using the same protocol underscores the subtle nature of post-reactivation pharmacological memory interference. Notably, impoverished housing resulted in a decrease in contextual freezing during contextual fear conditioning, reactivation and retention testing, compared to enriched and standard housing conditions. This observation warrants caution when interpreting the results from experiments regarding effects of housing on fear memory processes, particularly when freezing is used as a measure of fear.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CONTEXTUAL FEAR CONDITIONING
dc.subject
ENRICHED HOUSING
dc.subject
FREEZING
dc.subject
IMPOVERISHED HOUSING
dc.subject
POST-REACTIVATION AMNESIA
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T15:10:00Z
dc.journal.volume
359
dc.journal.pagination
172-180
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Schroyens, Natalie. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Bender, Crhistian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Alfei Palloni, Joaquin Matías. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Luyten, Laura. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Beckers, Tom. Katholikie Universiteit Leuven; Bélgica
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbr.2018.10.040
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818313068


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