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dc.contributor.author
Artur de la Villarmois, Emilce
dc.contributor.author
Constantin, Maria Florencia
dc.contributor.author
Bregonzio Diaz, Claudia
dc.contributor.author
Perez, Maria Fernanda
dc.date.available
2019-11-25T12:33:23Z
dc.date.issued
2018-01
dc.identifier.citation
Artur de la Villarmois, Emilce; Constantin, Maria Florencia; Bregonzio Diaz, Claudia; Perez, Maria Fernanda; Diazepam withdrawal expression is related to hippocampal NOS-1 upregulation; Heighten Science Publications; Archives of Pharmacy and Pharmaceutical Sciences; 2; 1; 1-2018; 001-009
dc.identifier.issn
2576-9537
dc.identifier.uri
http://hdl.handle.net/11336/89634
dc.description.abstract
Benzodiazepines are usually prescribed for anxiety and sleep disorders in a long-term fashion that may cause drug dependence. Discontinuation after prolonged administration may lead to withdrawal expression, being anxiety the most predominant sign. It has been described that a context-dependent associative learning process underlies diazepam dependence. Nitric oxide is a crucial player in learning and memory processes, hippocampal transmission, as well as in benzodiazepines withdrawal. Considering that previous results from our laboratory showed an increase in hippocampal functional plasticity only in diazepam dependent rats, the aim of the present investigation is to determine whether diazepam dependence could alter neuronal nitric oxide synthase enzyme (NOS-1) expression within the hippocampus, by using western blot.Results: chronic diazepam-treated animals that developed dependence showed increase in NOS-1 expression in dorsal, but not in ventral hippocampus, while no-dependent or control animals presented similar NOS-1 protein levels.Conclusion: withdrawal from long-term diazepam exposure could be associated to increased nitric oxide neurotransmission within dorsal hippocampus induced by NOS-1 over-expression. This mechanism could underlie the improved hippocampal synaptic transmission previously observed in diazepam withdrawn animals. Confirmatory experiments need to be addressed to determine the mechanisms by which nitric oxide participates in benzodiazepines withdrawal in order find new molecular targets to develop pharmacological tools to prevent the withdrawal syndrome
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Heighten Science Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nitric Oxide Sintase
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Hippocampus
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Diazepam dependence
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Diazepam withdrawal expression is related to hippocampal NOS-1 upregulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T15:07:34Z
dc.journal.volume
2
dc.journal.number
1
dc.journal.pagination
001-009
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Flower Mound
dc.description.fil
Fil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Constantin, Maria Florencia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
dc.description.fil
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Perez, Maria Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
dc.journal.title
Archives of Pharmacy and Pharmaceutical Sciences
dc.relation.isreferencedin
info:eu-repo/semantics/reference/url/https://www.heighpubs.org/hps/pdf/apps-aid1006.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.29328/journal.hps.1001006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.heighpubs.org/hps/apps-aid1006.php
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