Mostrar el registro sencillo del ítem
dc.contributor.author
Salguero Salas, Yadira Estefania
dc.contributor.author
García, Mónica Cristina
dc.contributor.author
Mosconi, Giuliana
dc.contributor.author
Rojas Delgado, Ricardo
dc.date.available
2019-11-22T17:31:02Z
dc.date.issued
2018-10-31
dc.identifier.citation
Salguero Salas, Yadira Estefania; García, Mónica Cristina; Mosconi, Giuliana; Rojas Delgado, Ricardo; Structural and morphological aspects of (fluoro) quinolone delivery by layered double hydroxide nanoparticles; Royal Society of Chemistry; New Journal of Chemistry; 42; 23; 31-10-2018; 19144-19152
dc.identifier.issn
1144-0546
dc.identifier.uri
http://hdl.handle.net/11336/89576
dc.description.abstract
Layered double hydroxides (LDHs) have been proposed as delivery systems (DSs) of (fluoro)quinolones (QLNs) to overcome their low bioavailability and to prevent the emergence of resistant bacteria. Both LDH-DS synthesis as nanoparticles (NPs) and QLN interactions with the metal ions that constitute the layers are essential to improve their physicochemical, biopharmaceutical and antimicrobial properties. Here, LDH-DSs containing the basic form of nalidixic acid (Nal), used as a probe, were obtained by coprecipitation at variable and constant pH (LDH-Nal-pHvar and LDH-Nal-pHcte, respectively). For both syntheses, LDH NPs containing Nal anions (LDH-Nal-NPs), with sizes between 30 and 40 nm, were obtained. A coordination compound (Mg(Nal)2·4H2O, Mg(Nal)2) was also concurrent for LDH-Nal-pHcte, which modulated the drug release profile and antimicrobial properties of the LDH-Nal-NPs. Thus, Nal release from LDH-Nal-pHvar was produced mainly by anion exchange. The best fits, obtained for the Higuchi model, showed rate constants dependent on the exchanging anions (kH = 0.88 and 1.53 for NaCl 0.9% and buffer phosphate 0.05 M, pH = 7.4, respectively). The nanometric size of LDH-Nal-pHvar as well as its faster release rate allowed a minimum inhibitory concentration decrease (MIC = 32 μg mL−1) compared to the pure drug (MIC = 128 μg mL−1). Instead, the presence of Mg(Nal)2 in LDH-Nal-pHcte led to a more sustained and media independent Nal release, but a lower MIC (64 μg mL−1) than LDH-Nal-pHvar.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nalidixic acid
dc.subject
Particle size
dc.subject
Antimicrobial
dc.subject
Anion exchange
dc.subject.classification
Química Coloidal
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Farmacología y Farmacia
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Structural and morphological aspects of (fluoro) quinolone delivery by layered double hydroxide nanoparticles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-30T18:28:26Z
dc.identifier.eissn
1369-9261
dc.journal.volume
42
dc.journal.number
23
dc.journal.pagination
19144-19152
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Salguero Salas, Yadira Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Mosconi, Giuliana. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
dc.description.fil
Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.journal.title
New Journal of Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/nj/c8nj03072c#!divAbstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c8nj03072c
Archivos asociados