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dc.contributor.author
Colmegna, Patricio Hernán
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dc.contributor.author
Sanchez Peña, Ricardo Salvador
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dc.contributor.author
Gondhalekar, Ravi
dc.contributor.author
Dassau, Eyal
dc.contributor.author
Doyle, Francis J.
dc.date.available
2019-11-22T14:51:46Z
dc.date.issued
2016-05
dc.identifier.citation
Colmegna, Patricio Hernán; Sanchez Peña, Ricardo Salvador; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Francis J.; Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control: In Silico Studies; SAGE Publications; Journal of Diabetes Science and Technology; 10; 3; 5-2016; 744-753
dc.identifier.issn
1932-2968
dc.identifier.uri
http://hdl.handle.net/11336/89545
dc.description.abstract
Background: Time-varying dynamics is one of the main issues for achieving safe blood glucose control in type 1 diabetes mellitus (T1DM) patients. In addition, the typical disturbances considered for controller design are meals, which increase the glucose level, and physical activity (PA), which increases the subject's sensitivity to insulin. In previous works the authors have applied a linear parameter-varying (LPV) control technique to manage unannounced meals. Methods: A switched LPV controller that switches between 3 LPV controllers, each with a different level of aggressiveness, is designed to further cope with both unannounced meals and postprandial PA. Thus, the proposed control strategy has a "standard" mode, an "aggressive" mode, and a "conservative" mode. The "standard" mode is designed to be applied most of the time, while the "aggressive" mode is designed to deal only with hyperglycemia situations. On the other hand, the "conservative" mode is focused on postprandial PA control. Results: An ad hoc simulator has been developed to test the proposed controller. This simulator is based on the distribution version of the UVA/Padova model and includes the effect of PA based on Schiavon.1 The test results obtained when using this simulator indicate that the proposed control law substantially reduces the risk of hypoglycemia with the conservative strategy, while the risk of hyperglycemia is scarcely affected. Conclusions: It is demonstrated that the announcement, or anticipation, of exercise is indispensable for letting a mono-hormonal artificial pancreas deal with the consequences of postprandial PA. In view of this the proposed controller allows switching into a conservative mode when notified of PA by the user.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LINEAR PARAMETER-VARYING CONTROL
dc.subject
POSTPRANDIAL PHYSICAL ACTIVITY
dc.subject
SWITCHED SYSTEMS
dc.subject
TYPE 1 DIABETES MELLITUS
dc.subject.classification
Sistemas de Automatización y Control
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dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control: In Silico Studies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-15T15:31:31Z
dc.journal.volume
10
dc.journal.number
3
dc.journal.pagination
744-753
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Colmegna, Patricio Hernán. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sanchez Peña, Ricardo Salvador. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina
dc.description.fil
Fil: Gondhalekar, Ravi. University of California; Estados Unidos
dc.description.fil
Fil: Dassau, Eyal. Harvard University; Estados Unidos
dc.description.fil
Fil: Doyle, Francis J.. Harvard University; Estados Unidos
dc.journal.title
Journal of Diabetes Science and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1932296816638857
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/1932296816638857
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