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dc.contributor.author
Miceli, Diego Daniel
dc.contributor.author
Abiuso, Adriana María Belén
dc.contributor.author
Vidal, Patricia Noemi
dc.contributor.author
Gallelli, Maria Florencia
dc.contributor.author
Pignataro, Omar Pedro
dc.contributor.author
Castillo, Victor Alejandro
dc.date.available
2019-11-21T22:08:05Z
dc.date.issued
2018-03
dc.identifier.citation
Miceli, Diego Daniel; Abiuso, Adriana María Belén; Vidal, Patricia Noemi; Gallelli, Maria Florencia; Pignataro, Omar Pedro; et al.; Overexpression of 11β-hydroxysteroid dehydrogenase 1 in visceral adipose tissue and underexpression of endothelial nitric oxide synthase in the adrenal cortex of dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 1; 3-2018; 77-85
dc.identifier.issn
2226-4485
dc.identifier.uri
http://hdl.handle.net/11336/89505
dc.description.abstract
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) is an enzyme that activates cortisone into cortisol in tissues. Alterations in this enzyme are related to the development of metabolic syndrome, obesity and hyperadrenocorticism (HAC). Endothelial nitric oxide synthase (eNOS) produces nitric oxide and is related to the regulation of adrenal steroidogenesis. The aim of the study was to evaluate 11β-HSD1 and eNOS expression in dogs with HAC. Visceral adipose tissue samples were taken to evaluate 11β-HSD1 expression by immunohistochemistry and western blotting. In parallel, adrenal gland samples were collected to evaluate eNOS expression by immunohistochemistry. 11β-HSD1 expression was significantly higher in the adipocytes of dogs with HAC than in those of the control dogs. eNOS expression in the adrenal cortex (zona fasciculata) was significantly lower in the dogs with HAC than in the control dogs. 11β-HSD1 overexpression and eNOS underexpression could play a role in the maintenance of hypercortisolism in dogs with HAC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
University of Tripoli. Faculty of Veterinary Medicine
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
11 Beta;-HSD1
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ENOS
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GLUCOCORTICOIDS
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HYPERADRENOCORTICISM
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Overexpression of 11β-hydroxysteroid dehydrogenase 1 in visceral adipose tissue and underexpression of endothelial nitric oxide synthase in the adrenal cortex of dogs with hyperadrenocorticism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T15:23:27Z
dc.journal.volume
8
dc.journal.number
1
dc.journal.pagination
77-85
dc.journal.pais
Libia
dc.journal.ciudad
Tripoli
dc.description.fil
Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Abiuso, Adriana María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Gallelli, Maria Florencia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
Open Veterinary Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/168603
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918128/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4314/ovj.v8i1.13
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