Noncoding RNAs and base modifications: epigenomic players implicated in neurological disorders and tumorigenesis

Abstract

Epigenetics is defined as the study of gene expression regulations by nongenetic but heritable other than DNA sequence variations. The epigenetic memories stored in the base modifications and histone modifications such as methylation, phosphorylation, and acetylation play important roles in regulation of all the metabolic pathways. Any aberrant alterations could lead to developmental abnormalities of diverse diseases including neurological disorders and cancers.