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dc.contributor.author
Imperiale, Belén Rocío
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dc.contributor.author
Morcillo, Nora Susana
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dc.contributor.author
Palomino, Juan Carlos
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dc.contributor.author
Vandamme, Peter
dc.contributor.author
Martin, Anandi
dc.date.available
2019-11-20T23:08:48Z
dc.date.issued
2014-04
dc.identifier.citation
Imperiale, Belén Rocío; Morcillo, Nora Susana; Palomino, Juan Carlos; Vandamme, Peter; Martin, Anandi; Predictive value of direct nitrate reductase assay and its clinical performance in the detection of multi- and extensively drug-resistant tuberculosis; Society for General Microbiology; Journal Of Medical Microbiology; 63; Part 4; 4-2014; 522-527
dc.identifier.issn
0022-2615
dc.identifier.uri
http://hdl.handle.net/11336/89354
dc.description.abstract
Conventional culture and drug susceptibility testing (DST) methods for Mycobacterium tuberculosis are laborious and time consuming. For this reason alternative rapid culture and DST techniques are urgently needed to shorten the time for drug-resistance detection. A total of 222 smear-positive sputum samples were evaluated by the direct nitrate reductase assay (D-NRA) on Lowenstein-Jensen medium, for the rapid and simultaneous detection of resistance to isoniazid, rifampicin, kanamycin and ofloxacin. p-Nitrobenzoic acid was also included for identification of the M. tuberculosis complex. Results were compared with the BACTEC MGIT 960 as gold standard. The general performance of the D-NRA was very good, reaching a global value of 97 %. D-NRA had a turn-around time of 16.9 days to obtain results while that of the indirect MGIT 960 system was 29 days. D-NRA is a low-cost technology, easy to set up in clinical laboratories and suitable to be used for DST of M. tuberculosis in all smear-positive samples. © 2014 SGM.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for General Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MYCOBACTERIUM TUBERCULOSIS
dc.subject
DIRECT NITRATE REDUCTASE ASSAY
dc.subject
MULTIDRUG-RESISTANT TUBERCULOSIS
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Predictive value of direct nitrate reductase assay and its clinical performance in the detection of multi- and extensively drug-resistant tuberculosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-28T14:33:01Z
dc.journal.volume
63
dc.journal.number
Part 4
dc.journal.pagination
522-527
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
dc.description.fil
Fil: Morcillo, Nora Susana. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
dc.description.fil
Fil: Palomino, Juan Carlos. University of Ghent; Bélgica
dc.description.fil
Fil: Vandamme, Peter. University of Ghent; Bélgica
dc.description.fil
Fil: Martin, Anandi. University of Ghent; Bélgica
dc.journal.title
Journal Of Medical Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1099/jmm.0.070219-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.070219-0
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