Mostrar el registro sencillo del ítem
dc.contributor.author
Díaz-Viraqué, Florencia
dc.contributor.author
Chiribao, María Laura
dc.contributor.author
Trochine, Andrea
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
González Herrera, Fabiola
dc.contributor.author
Castillo, Christian
dc.contributor.author
Liempi, Ana
dc.contributor.author
Kemmerling, Ulrike
dc.contributor.author
Maya, Juan Diego
dc.contributor.author
Robello, Carlos
dc.date.available
2019-11-20T19:02:48Z
dc.date.issued
2018-03
dc.identifier.citation
Díaz-Viraqué, Florencia; Chiribao, María Laura; Trochine, Andrea; González Herrera, Fabiola; Castillo, Christian; et al.; Old Yellow Enzyme from Trypanosoma cruzi exhibits in vivo Prostaglandin F2α synthase activity and has a key role in parasite infection and drug susceptibility; Frontiers Media SA; Frontiers in Immunology; 9; 3-2018; 456-469
dc.identifier.issn
1664-3224
dc.identifier.uri
http://hdl.handle.net/11336/89314
dc.description.abstract
The discovery that trypanosomatids, unicellular organisms of the order Kinetoplastida, are capable of synthesizing prostaglandins raised questions about the role of these molecules during parasitic infections. Multiple studies indicate that prostaglandins could be related to the infection processes and pathogenesis in trypanosomatids. This work aimed to unveil the role of the prostaglandin F2α synthase TcOYE in the establishment of Trypanosoma cruzi infection, the causative agent of Chagas disease. This chronic disease affects several million people in Latin America causing high morbidity and mortality. Here, we propose a prokaryotic evolutionary origin for TcOYE, and then we used in vitro and in vivo experiments to show that T. cruzi prostaglandin F2α synthase plays an important role in modulating the infection process. TcOYE overexpressing parasites were less able to complete the infective cycle in cell culture infections and increased cardiac tissue parasitic load in infected mice. Additionally, parasites overexpressing the enzyme increased PGF2α synthesis from arachidonic acid. Finally, an increase in benznidazole and nifurtimox susceptibility in TcOYE overexpressing parasites showed its participation in activating the currently anti-chagasic drugs, which added to its observed ability to confer resistance to hydrogen peroxide, highlights the relevance of this enzyme in multiple events including host-parasite interaction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media SA
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BENZNIDAZOL AND NIFURTIMOX ACTIVATION
dc.subject
DIFFERENTIALLY EXPRESSED GENE
dc.subject
OLD YELLOW ENZYME
dc.subject
PROSTAGLANDIN F2A SYNTHASE
dc.subject
TRYPANOSOMA CRUZI
dc.subject.classification
Bioquímica y Biología Molecular
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Old Yellow Enzyme from Trypanosoma cruzi exhibits in vivo Prostaglandin F2α synthase activity and has a key role in parasite infection and drug susceptibility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-28T19:35:50Z
dc.journal.volume
9
dc.journal.pagination
456-469
dc.journal.pais
Suiza
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Lausana
dc.description.fil
Fil: Díaz-Viraqué, Florencia. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Chiribao, María Laura. Instituto Pasteur de Montevideo; Uruguay. Universidad de la República; Uruguay
dc.description.fil
Fil: Trochine, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales.; Argentina. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: González Herrera, Fabiola. Universidad de Chile; Chile
dc.description.fil
Fil: Castillo, Christian. Universidad de Chile; Chile
dc.description.fil
Fil: Liempi, Ana. Universidad de Chile; Chile
dc.description.fil
Fil: Kemmerling, Ulrike. Universidad de Chile; Chile
dc.description.fil
Fil: Maya, Juan Diego. Universidad de Chile; Chile
dc.description.fil
Fil: Robello, Carlos. Instituto Pasteur de Montevideo; Uruguay. Universidad de la República; Uruguay
dc.journal.title
Frontiers in Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2018.00456
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2018.00456/full
Archivos asociados