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dc.contributor.author
Rey Ares, Veronica  
dc.contributor.author
Rossi, Soledad Paola  
dc.contributor.author
Dietrich, Kim Gwendolyn  
dc.contributor.author
Köhn, Frank Michael  
dc.contributor.author
Ullrich Schwarzer, J  
dc.contributor.author
Welter, Hared  
dc.contributor.author
Frungieri, Monica Beatriz  
dc.contributor.author
Mayerhofer, Artur  
dc.date.available
2019-11-19T20:15:38Z  
dc.date.issued
2018-09  
dc.identifier.citation
Rey Ares, Veronica; Rossi, Soledad Paola; Dietrich, Kim Gwendolyn; Köhn, Frank Michael; Ullrich Schwarzer, J; et al.; Prostaglandin E 2 (PGE 2 ) is a testicular peritubular cell-derived factor involved in human testicular homeostasis; Elsevier Ireland; Molecular and Cellular Endocrinology; 473; 9-2018; 217-224  
dc.identifier.issn
0303-7207  
dc.identifier.uri
http://hdl.handle.net/11336/89220  
dc.description.abstract
In man, blockage of prostaglandin (PG)-production e.g. by non-steroidal anti-inflammatory drug (NSAIDs) may have negative testicular side effects, implying beneficial actions of PGs in the testis. We examined human testicular samples and isolated human testicular peritubular cells (HTPCs) to explore sites of PG-synthesis and targets. HTPCs express cyclooxygenase 1 (COX1) and secrete PGE 2 . Receptors (EP1, 2, 4) were specifically identified in peritubular cells. In HTPCs PGE 2 significantly increased mRNA levels of the contractility protein calponin, but did not induce contractions. PGE 2 , as well as EP1 and EP4 receptor agonists, significantly increased glia cell line derived neurotrophic factor (GDNF) mRNA and/or protein levels. Importantly, the NSAID ibuprofen reduced PGE 2 and this action also lowered SMA and calponin mRNA levels and levels of secreted GDNF protein. The results reveal an unknown PGE 2 system in the human testis, in involving peritubular cells, which may be prone to interference by NSAIDs.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTI-INFLAMMATORY DRUGS  
dc.subject
GDNF  
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MALE FERTILITY  
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MALE INFERTILITY  
dc.subject
TESTIS  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Prostaglandin E 2 (PGE 2 ) is a testicular peritubular cell-derived factor involved in human testicular homeostasis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-09-27T15:23:10Z  
dc.journal.volume
473  
dc.journal.pagination
217-224  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Rey Ares, Veronica. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Rossi, Soledad Paola. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Dietrich, Kim Gwendolyn. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Köhn, Frank Michael. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Ullrich Schwarzer, J. Andrologicum; Múnich, Alemania; Alemania  
dc.description.fil
Fil: Welter, Hared. Ludwig Maximilians Universitat; Alemania  
dc.description.fil
Fil: Frungieri, Monica Beatriz. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania  
dc.journal.title
Molecular and Cellular Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720718300455?via%3Dihub  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2018.01.022  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/29408603