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dc.contributor.author
Rey Ares, Veronica
dc.contributor.author
Rossi, Soledad Paola
dc.contributor.author
Dietrich, Kim Gwendolyn
dc.contributor.author
Köhn, Frank Michael
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Ullrich Schwarzer, J
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Welter, Hared
dc.contributor.author
Frungieri, Monica Beatriz
dc.contributor.author
Mayerhofer, Artur
dc.date.available
2019-11-19T20:15:38Z
dc.date.issued
2018-09
dc.identifier.citation
Rey Ares, Veronica; Rossi, Soledad Paola; Dietrich, Kim Gwendolyn; Köhn, Frank Michael; Ullrich Schwarzer, J; et al.; Prostaglandin E 2 (PGE 2 ) is a testicular peritubular cell-derived factor involved in human testicular homeostasis; Elsevier Ireland; Molecular and Cellular Endocrinology; 473; 9-2018; 217-224
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/89220
dc.description.abstract
In man, blockage of prostaglandin (PG)-production e.g. by non-steroidal anti-inflammatory drug (NSAIDs) may have negative testicular side effects, implying beneficial actions of PGs in the testis. We examined human testicular samples and isolated human testicular peritubular cells (HTPCs) to explore sites of PG-synthesis and targets. HTPCs express cyclooxygenase 1 (COX1) and secrete PGE 2 . Receptors (EP1, 2, 4) were specifically identified in peritubular cells. In HTPCs PGE 2 significantly increased mRNA levels of the contractility protein calponin, but did not induce contractions. PGE 2 , as well as EP1 and EP4 receptor agonists, significantly increased glia cell line derived neurotrophic factor (GDNF) mRNA and/or protein levels. Importantly, the NSAID ibuprofen reduced PGE 2 and this action also lowered SMA and calponin mRNA levels and levels of secreted GDNF protein. The results reveal an unknown PGE 2 system in the human testis, in involving peritubular cells, which may be prone to interference by NSAIDs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTI-INFLAMMATORY DRUGS
dc.subject
GDNF
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MALE FERTILITY
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MALE INFERTILITY
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TESTIS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Prostaglandin E 2 (PGE 2 ) is a testicular peritubular cell-derived factor involved in human testicular homeostasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T15:23:10Z
dc.journal.volume
473
dc.journal.pagination
217-224
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Rey Ares, Veronica. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Rossi, Soledad Paola. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Dietrich, Kim Gwendolyn. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Köhn, Frank Michael. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Ullrich Schwarzer, J. Andrologicum; Múnich, Alemania; Alemania
dc.description.fil
Fil: Welter, Hared. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Frungieri, Monica Beatriz. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania
dc.journal.title
Molecular and Cellular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720718300455?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2018.01.022
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/29408603
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