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dc.contributor.author
Lopez Cascales, Jose Javier
dc.contributor.author
Zenak, Siham
dc.contributor.author
García de La Torre, José
dc.contributor.author
Lezama, José Osvaldo Guy
dc.contributor.author
Garro, Adriana
dc.contributor.author
Enriz, Ricardo Daniel
dc.date.available
2019-11-14T21:53:07Z
dc.date.issued
2018-05
dc.identifier.citation
Lopez Cascales, Jose Javier; Zenak, Siham; García de La Torre, José; Lezama, José Osvaldo Guy; Garro, Adriana; et al.; Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity; American Chemical Society; ACS Omega; 3; 5; 5-2018; 5390-5398
dc.identifier.issn
2470-1343
dc.identifier.uri
http://hdl.handle.net/11336/89006
dc.description.abstract
The first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
MD simulations
dc.subject
cationic peptides
dc.subject
antibacterial agents
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-02T19:42:53Z
dc.journal.volume
3
dc.journal.number
5
dc.journal.pagination
5390-5398
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
dc.description.fil
Fil: Zenak, Siham. Universitédes Sciences et de la Technologie d’Oran; Argelia
dc.description.fil
Fil: García de La Torre, José. Universidad de Murcia; España
dc.description.fil
Fil: Lezama, José Osvaldo Guy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.description.fil
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.journal.title
ACS Omega
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.8b00293
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1021/acsomega.8b00293
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130792/
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