Artículo
Receptor-mediated endocytosis and trafficking between endosomal–lysosomal vacuoles in Giardia lamblia
Rivero, Maria Romina
; Jausoro, Ignacio
; Bisbal, Mariano
; Feliziani, Constanza
; Lanfredi Rangel, Adriana; Touz, Maria Carolina
Fecha de publicación:
04/2013
Editorial:
Springer
Revista:
Parasitology Research
ISSN:
0932-0113
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The early branching Giardia lamblia has highly polarized vacuoles, located underneath the plasma membrane, which have at least some of the characteristics of endosomes and of lysosomes. These peripheral vacuoles (PVs) are necessary for nutrient uptake and the maintenance of plasma membrane composition, but whether they carry out sorting and segregation of receptors and ligands is a matter of debate. Here, we showed that the internalization of low-density lipoprotein (LDL) to the PVs is highly dynamic in trophozoites with a rate similar to the internalization of the low-density lipoprotein receptor-related protein 1. Moreover, by analyzing receptor-mediated and fluid-phase endocytosis in living cells, we showed that after endocytosis LDL but not dextran moved laterally between the PVs. We speculate on PV functional heterogeneity and maturation in this parasite.
Palabras clave:
Giardia I
,
Lamblia
,
Endocytosis
,
Tirf
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Rivero, Maria Romina; Jausoro, Ignacio; Bisbal, Mariano; Feliziani, Constanza; Lanfredi Rangel, Adriana; et al.; Receptor-mediated endocytosis and trafficking between endosomal–lysosomal vacuoles in Giardia lamblia; Springer; Parasitology Research; 112; 4; 4-2013; 1813-1818
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