Induction of quinone reductase by withanolides

Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland.

Palabras clave: WITHANOLIDES , QUINONE REDUCTASE

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/88909

URL: http://pubs.acs.org/doi/full/10.1021/np0106337

DOI: http://dx.doi.org/10.1021/np0106337

Colecciones

Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Misico, Rosana Isabel; Song, Lynda L.; Veleiro, Adriana Silvia; Cirigliano, Adriana Monica; Tettamanzi, María C.; et al.; Induction of quinone reductase by withanolides; American Chemical Society; Journal of Natural Products; 65; 5; 4-2002; 677-680

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