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dc.contributor.author
Duhart, José Manuel
dc.contributor.author
Leone, Maria Juliana
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Paladino, Natalia
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Evans, J. A.
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Castanon Cervantes, O.
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Davidson, A. J.
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Golombek, Diego Andrés
dc.date.available
2019-11-13T22:18:36Z
dc.date.issued
2013-11
dc.identifier.citation
Duhart, José Manuel; Leone, Maria Juliana; Paladino, Natalia; Evans, J. A.; Castanon Cervantes, O.; et al.; Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α; American Association of Immunologists; Journal of Immunology; 191; 9; 11-2013; 4656-4664
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/88822
dc.description.abstract
The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, responds to peripheral and local immune stimuli, such as proinflammatory cytokines and bacterial endotoxin. Astrocytes exert several immune functions in the CNS, and there is growing evidence that points toward a role of these cells in the regulation of circadian rhythms. The aim of this work was to assess the response of SCN astrocytes to immune stimuli, particularly to the proinflammatory cytokine TNF-a. TNF-α applied to cultures of SCN astrocytes from Per2 luc knockin mice altered both the phase and amplitude of PER2 expression rhythms, in a phase-dependent manner. Furthermore, conditioned media from SCN astrocyte cultures transiently challenged with TNF-a induced an increase in Per1 expression in NIH 3T3 cells, which was blocked by TNF-a antagonism. In addition, these conditioned media could induce phase shifts in SCN PER2 rhythms and, when administered intracerebroventricularly, induced phase delays in behavioral circadian rhythms and SCN activation in control mice, but not in TNFR-1 mutants. In summary, our results show that TNF-a modulates the molecular clock of SCN astrocytes in vitro, and also that, in response to this molecule, SCN astrocytes can modulate clock gene expression in other cells and tissues, and induce phase shifts in a circadian behavioral output in vivo. These findings suggest a role for astroglial cells in the alteration of circadian timing by immune activation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Astrocytes
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Cytokines
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Circadian rhythms
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Suprachiasmatic nuclei
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:45:19Z
dc.journal.volume
191
dc.journal.number
9
dc.journal.pagination
4656-4664
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Duhart, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.description.fil
Fil: Leone, Maria Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.description.fil
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.description.fil
Fil: Evans, J. A.. Neuroscience Institute; Estados Unidos
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Fil: Castanon Cervantes, O.. Morehouse School of Medicine; Estados Unidos
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Fil: Davidson, A. J.. Morehouse School of Medicine; Estados Unidos
dc.description.fil
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.journal.title
Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.1300450
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jimmunol.org/content/191/9/4656
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811024/
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