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dc.contributor.author
Goss, William Miller
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dc.contributor.author
Seas, Carlos
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Carvajal, Lina P.
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Diaz, Lorena
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Echeverri, Aura M.
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Ferro, Carolina
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Rios, Rafael
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Porras, Paola
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Luna, Carlos
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Gotuzzo, Eduardo
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Munita, Jose M.
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Nannini, Esteban
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Carcamo, Cesar
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Reyes, Jinnethe
dc.contributor.author
Arias, Cesar A.
dc.date.available
2019-11-12T13:50:21Z
dc.date.issued
2018-05
dc.identifier.citation
Goss, William Miller; Seas, Carlos; Carvajal, Lina P.; Diaz, Lorena; Echeverri, Aura M.; et al.; The cefazolin inoculum effect is associated with increased mortality in methicillin-susceptible staphylococcus aureus bacteremia; Oxford University Press; Open Forum Infectious Diseases; 5; 6; 5-2018; 1-9
dc.identifier.issn
2328-8957
dc.identifier.uri
http://hdl.handle.net/11336/88583
dc.description.abstract
Background. Recent studies have favored the use of cefazolin over nafcillin for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The clinical influence of the cefazolin inoculum effect (CzIE) in the effectiveness of cephalosporins for severe MSSA infections has not been evaluated. Methods. We prospectively included patients from 3 Argentinian hospitals with S. aureus bacteremia. Cefazolin minimum inhibitory concentrations (MICs) were determined at standard (105 colony-forming units [CFU]/mL) and high (107 CFU/mL) inoculum. The CzIE was defined as an increase of MIC to ≥16 µg/mL when tested at high inoculum. Whole-genome sequencing was performed in all isolates. Results. A total of 77 patients, contributing 89 MSSA isolates, were included in the study; 42 patients (54.5%) had isolates with the CzIE. In univariate analysis, patients with MSSA exhibiting the CzIE had increased 30-day mortality (P = .034) and were more likely to have catheter-associated or unknown source of bacteremia (P = .033) compared with patients infected with MSSA isolates without the CzIE. No statistically significant difference between the groups was observed in age, clinical illness severity, place of acquisition (community vs hospital), or presence of endocarditis. The CzIE remained associated with increased 30-day mortality in multivariate analysis (risk ratio, 2.65; 95% confidence interval, 1.10-6.42; P = .03). MSSA genomes displayed a high degree of heterogeneity, and the CzIE was not associated with a specific lineage. Conclusions. In patients with MSSA bacteremia where cephalosporins are used as firstline therapy, the CzIE was associated with increased 30-day mortality. Clinicians should be cautious when using cefazolin as firstline therapy for these infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CEPHALOSPORINS
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ENDOCARDITIS
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INOCULUM EFFECT
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METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS AUREUS
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Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The cefazolin inoculum effect is associated with increased mortality in methicillin-susceptible staphylococcus aureus bacteremia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-18T19:13:50Z
dc.identifier.eissn
2328-8957
dc.journal.volume
5
dc.journal.number
6
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
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Fil: Goss, William Miller. University of Texas; Estados Unidos
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Fil: Seas, Carlos. Universidad Peruana Cayetano Heredia; Perú
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Fil: Carvajal, Lina P.. Universidad El Bosque; Colombia
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Fil: Diaz, Lorena. Universidad El Bosque; Colombia. UTHealth McGovern Medical School; Estados Unidos
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Fil: Echeverri, Aura M.. Universidad El Bosque; Colombia
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Fil: Ferro, Carolina. Universidad El Bosque; Colombia
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Fil: Rios, Rafael. Universidad El Bosque; Colombia
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Fil: Porras, Paola. Universidad El Bosque; Colombia
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Fil: Luna, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
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Fil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; Perú
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Fil: Munita, Jose M.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
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Fil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
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Fil: Carcamo, Cesar. Universidad Peruana Cayetano Heredia; Perú
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Fil: Reyes, Jinnethe. Universidad El Bosque; Colombia
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Fil: Arias, Cesar A.. University of Texas; Estados Unidos
dc.journal.title
Open Forum Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ofid/ofy123
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ofid/article/5/6/ofy123/5003417
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