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dc.contributor.author
Schor, Ignacio Esteban
dc.contributor.author
Bussotti, Giovanni
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Maleš, Matilda
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Forneris, Mattia
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Viales, Rebecca R.
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Enright, Anton J.
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Furlong, Eileen E. M.
dc.date.available
2019-11-11T19:01:09Z
dc.date.issued
2018-11
dc.identifier.citation
Schor, Ignacio Esteban; Bussotti, Giovanni; Maleš, Matilda; Forneris, Mattia; Viales, Rebecca R.; et al.; Non-coding RNA Expression, Function, and Variation during Drosophila Embryogenesis; Cell Press; Current Biology; 28; 22; 11-2018; 3547-3561.e9
dc.identifier.issn
0960-9822
dc.identifier.uri
http://hdl.handle.net/11336/88518
dc.description.abstract
Long non-coding RNAs (lncRNAs) can often function in the regulation of gene expression during development; however, their generality as essential regulators in developmental processes and organismal phenotypes remains unclear. Here, we performed a tailored investigation of lncRNA expression and function during Drosophila embryogenesis, interrogating multiple stages, tissue specificity, nuclear localization, and genetic backgrounds. Our results almost double the number of annotated lncRNAs expressed at these embryonic stages. lncRNA levels are generally positively correlated with those of their neighboring genes, with little evidence of transcriptional interference. Using fluorescent in situ hybridization, we report the spatiotemporal expression of 15 new lncRNAs, revealing very dynamic tissue-specific patterns. Despite this, deletion of selected lncRNA genes had no obvious developmental defects or effects on viability under standard and stressed conditions. However, two lncRNA deletions resulted in modest expression changes of a small number of genes, suggesting that they fine-tune expression of non-essential genes. Several lncRNAs have strain-specific expression, indicating that they are not fixed within the population. This intra-species variation across genetic backgrounds may thereby be a useful tool to distinguish rapidly evolving lncRNAs with as yet non-essential roles.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BYSTANDER EXPRESSION
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EMBRYONIC DEVELOPMENT
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GENETIC VARIATION
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LNCRNA
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NON-CODING RNA
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NON-ESSENTIAL GENES
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TRANSCRIPTION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Biología del Desarrollo
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Non-coding RNA Expression, Function, and Variation during Drosophila Embryogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T19:13:44Z
dc.journal.volume
28
dc.journal.number
22
dc.journal.pagination
3547-3561.e9
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. European Molecular Biology Laboratory; Alemania
dc.description.fil
Fil: Bussotti, Giovanni. European Bioinformatics Institute; Reino Unido
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Fil: Maleš, Matilda. European Molecular Biology Laboratory; Alemania
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Fil: Forneris, Mattia. European Molecular Biology Laboratory; Alemania
dc.description.fil
Fil: Viales, Rebecca R.. European Molecular Biology Laboratory; Alemania
dc.description.fil
Fil: Enright, Anton J.. European Bioinformatics Institute; Reino Unido
dc.description.fil
Fil: Furlong, Eileen E. M.. European Molecular Biology Laboratory; Alemania
dc.journal.title
Current Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2018.09.026
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982218312211
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