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Artículo

Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase

Prado, Natalia JorgelinaIcon ; Casarotto, Mariana; Calvo, Juan Pablo; Mazzei, Luciana JorgelinaIcon ; Ponce Zumino, Amira ZulmaIcon ; García, Isabel Mercedes; Cuello Carrión, Fernando DaríoIcon ; Fornes, Miguel WalterIcon ; Diez, Emiliano RaúlIcon ; Manucha, Walter Ariel FernandoIcon
Fecha de publicación: 11/2018
Editorial: Wiley Blackwell Publishing, Inc
Revista: Journal of Pineal Research
ISSN: 0742-3098
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Lethal ventricular arrhythmias increase in patients with chronic kidney disease that suffer an acute coronary event. Chronic kidney disease induces myocardial remodeling, oxidative stress, and arrhythmogenesis. A manifestation of the relationship between kidney and heart is the concomitant reduction in vitamin D receptor (VDR) and the increase in angiotensin II receptor type 1 (AT1). Melatonin has renal and cardiac protective actions. One potential mechanism is the increase in the heat shock protein 70 (Hsp70)—an antioxidant factor. We aim to determine the mechanisms involved in melatonin (Mel) prevention of kidney damage and arrhythmogenic heart remodeling. Unilateral ureteral-obstruction (UUO) and sham-operated rats were treated with either melatonin (4 mg/kg/day) or vehicle for 15 days. Hearts and kidneys from obstructed rats showed a reduction in VDR and Hsp70. Associated with AT1 up-regulation in the kidneys and the heart of UUO rats also increased oxidative stress, fibrosis, apoptosis, mitochondrial edema, and dilated crests. Melatonin prevented these changes and ventricular fibrillation during reperfusion. The action potential lengthened and hyperpolarized in melatonin-treated rats throughout the experiment. We conclude that melatonin prevents renal damage and arrhythmogenic myocardial remodeling during unilateral ureteral obstruction due to a decrease in oxidative stress/fibrosis/apoptosis associated with AT1 reduction and Hsp70-VDR increase.
Palabras clave: ARRHYTHMIAS , CHRONIC KIDNEY DISEASE , CYTOPROTECTIVE EFFECTS , MELATONIN , OBSTRUCTIVE NEPHROPATHY , OXIDATIVE STRESS , REPERFUSION INJURY
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/88394
DOI: https://doi.org/10.1111/jpi.12513
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12513
Colecciones
Articulos(IMBECU) [384]
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos(IHEM) [262]
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Prado, Natalia Jorgelina; Casarotto, Mariana; Calvo, Juan Pablo; Mazzei, Luciana Jorgelina; Ponce Zumino, Amira Zulma; et al.; Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase; Wiley Blackwell Publishing, Inc; Journal of Pineal Research; 65; 4; 11-2018; 1-17
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