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Artículo

Deep hypothermia reverses behavioral and histological alterations in a rat model of perinatal asphyxia

Vazquez, PabloIcon ; Peña, Elena; Rojo, Yanina; Acuña, AndresIcon ; Loidl, Cesar FabianIcon
Fecha de publicación: 02/2019
Editorial: Wiley-liss, Div John Wiley & Sons Inc
Revista: Journal Of Comparative Neurology
ISSN: 0021-9967
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

The consequences of perinatal asphyxia (PA) include alterations which may manifest as schizophrenia. Characteristic features of this disease include a decrease in specific subpopulations of GABAergic cells and deterioration of social interaction. The purpose of this study is to assess if a deep and short-hypothermic treatment can ameliorate this damage in a model of PA. Rats offsprings were exposed to 19 min of asphyxia by immersing the uterus horns in water at 37 °C followed by 30 min in air at 10 °C that resulted in 15 °C body temperature. At postnatal day 36–38, the rats were tested in the open field and social interaction paradigms and processed for immunostaining of calbindin and reelin. A brief exposure to deep hypothermia reversed the deterioration produced by PA in play soliciting. PA decreased the density of calbindin neurons in layer II of the Anterior Insular Cortex, while deep hypothermia reversed this effect. Paradoxically, in AIC, there was a significant increase in the number of reelin-secreting neurons in layers II and III generated by PA and this increase was reversed by hypothermia. This suggests a compensatory mechanism, where reelin neurons trend to compensate for the loss of calbindin neurons, at least within Anterior Insular Cortex. Finally, the deep hypothermic shock might represent a valuable therapeutic alternative to treat PA.
Palabras clave: HYPOTHERMIA , PERINATAL HYPOXIA , RRID:AB_2336821 , RRID:AB_563448 , SCHIZOPHRENIA , SOCIAL INTERACTION RRID:AB_1603148
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/88379
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.24539
DOI: http://dx.doi.org/10.1002/cne.24539
Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
Vazquez, Pablo; Peña, Elena; Rojo, Yanina; Acuña, Andres; Loidl, Cesar Fabian; Deep hypothermia reverses behavioral and histological alterations in a rat model of perinatal asphyxia; Wiley-liss, Div John Wiley & Sons Inc; Journal Of Comparative Neurology; 527; 2; 2-2019; 362-371
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