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Artículo

Biochemical and Morphological Alterations in Hearts of Copper-Deficient Bovines

Olivares, Roberto Walter Israel; Postma, Gabriela Cintia; Schapira, Andrea; Iglesias, Dario EzequielIcon ; Valdez, Laura BatrizIcon ; Breininger, ElizabethIcon ; Gazzaneo, Pablo Daniel; Minatel, Leonardo
Fecha de publicación: 08/2018
Editorial: Humana Press
Revista: Biological Trace Element Research
ISSN: 0163-4984
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular; Otros Tópicos Biológicos

Resumen

Copper deficiency is an important disease of cattle that produces several clinical signs and lesions, due to alterations in copper-dependent enzymes. One of the organs affected by this deficiency is the heart (falling disease), but nevertheless, these cardiac lesions have not been extensively studied in bovines. The aim of this work was to propose a possible pathogenic mechanism for cardiac lesions in cattle affected by copper deficiency. Because of the possible existence of oxidative distress caused by low levels of copper-zinc-superoxide dismutase and cytochrome oxidase, ultrastructural and histological lesions have been evaluated in the heart of bovines in which a Cu deficiency had been induced using high molybdenum and sulfur levels in the diet. Our results indicated that copper deficiency produces significant damage in myocardium with high levels of lipid oxidation and a significant reduction in copper-zinc-superoxide dismutase activity leading to an oxidative distress situation. However, cytochrome oxidase activity was not significantly reduced. Histological observation revealed a significant increase in the amount of connective tissue, enlarged basement membranes of myocytes, and numerous Anichkov cells, in the hearts of deficient animals. Ultrastructural observation showed a significant enhancement in the mitochondrial volume density, with presence of lesions such as swelling and cristae disruption. We conclude that copper deficiency in bovines causes morphological lesions in the heart due to an oxidative damage produced by copper-dependent enzyme alterations.
Palabras clave: CALVES , COPPER , HEART , OXIDATIVE DISTRESS , ULTRASTRUCTURE
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/88355
DOI: http://dx.doi.org/10.1007/s12011-018-1476-x
URL: https://link.springer.com/article/10.1007%2Fs12011-018-1476-x
Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Olivares, Roberto Walter Israel; Postma, Gabriela Cintia; Schapira, Andrea; Iglesias, Dario Ezequiel; Valdez, Laura Batriz; et al.; Biochemical and Morphological Alterations in Hearts of Copper-Deficient Bovines; Humana Press; Biological Trace Element Research; 189; 2; 8-2018; 447-455
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