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dc.contributor.author
Meini, María Rocío
dc.contributor.author
Llarrull, Leticia Irene
dc.contributor.author
Vila, Alejandro Jose
dc.date.available
2016-12-05T19:54:29Z
dc.date.issued
2014-07
dc.identifier.citation
Meini, María Rocío; Llarrull, Leticia Irene; Vila, Alejandro Jose; Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution; MDPI; Antibiotics; 3; 3; 7-2014; 285-316
dc.identifier.issn
2079-6382
dc.identifier.uri
http://hdl.handle.net/11336/8813
dc.description.abstract
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able to hydrolyze not only penicillins, but also the latest generation of cephalosporins and carbapenems, which constitute at present the last resource antibiotics. The VIM, IMP, and NDM enzymes comprise the main groups of clinically relevant metallo-β-lactamases. Here we present an update of the features of the natural variants that have emerged and of the ones that have been engineered in the laboratory, in an effort to find sequence and structural determinants of substrate preferences. This knowledge is of upmost importance in novel drug design efforts. We also discuss the advances in knowledge achieved by means of in vitro directed evolution experiments, and the potential of this approach to predict natural evolution of metallo-β-lactamases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Resistance
dc.subject
Metallo-Β-Lactamases
dc.subject
Evolution
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T19:37:28Z
dc.journal.volume
3
dc.journal.number
3
dc.journal.pagination
285-316
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Meini, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Llarrull, Leticia Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.journal.title
Antibiotics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212336/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/antibiotics3030285
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