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dc.contributor.author
Weise, Stefan Christopher
dc.contributor.author
Villarreal, Alejandro
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dc.contributor.author
Heidrich, Stefanie
dc.contributor.author
Dehghanian, Fariba
dc.contributor.author
Schachtrup, Christian
dc.contributor.author
Nestel, Sigrun
dc.contributor.author
Schwarz, Jennifer
dc.contributor.author
Thedieck, Kathrin
dc.contributor.author
Vogel, Tanja
dc.date.available
2019-11-04T21:09:37Z
dc.date.issued
2018-11
dc.identifier.citation
Weise, Stefan Christopher; Villarreal, Alejandro; Heidrich, Stefanie; Dehghanian, Fariba; Schachtrup, Christian; et al.; TGFβ-signaling and FOXG1-expression are a hallmark of astrocyte lineage diversity in the murine ventral and dorsal forebrain; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 12; 448; 11-2018; 1-16
dc.identifier.issn
1662-5102
dc.identifier.uri
http://hdl.handle.net/11336/87973
dc.description.abstract
Heterogeneous astrocyte populations are defined by diversity in cellular environment, progenitor identity or function. Yet, little is known about the extent of the heterogeneity and how this diversity is acquired during development. To investigate the impact of TGF (transforming growth factor) β-signaling on astrocyte development in the telencephalon we deleted the TGFBR2 (transforming growth factor beta receptor 2) in early neural progenitor cells in mice using a FOXG1 (forkhead box G1)-driven CRE-recombinase. We used quantitative proteomics to characterize TGFBR2-deficient cells derived from the mouse telencephalon and identified differential protein expression of the astrocyte proteins GFAP (glial fibrillary acidic protein) and MFGE8 (milk fat globule-EGF factor 8). Biochemical and histological investigations revealed distinct populations of astrocytes in the dorsal and ventral telencephalon marked by GFAP or MFGE8 protein expression. The two subtypes differed in their response to TGFβ-signaling. Impaired TGFβ-signaling affected numbers of GFAP astrocytes in the ventral telencephalon. In contrast, TGFβ reduced MFGE8-expression in astrocytes deriving from both regions. Additionally, lineage tracing revealed that both GFAP and MFGE8 astrocyte subtypes derived partly from FOXG1-expressing neural precursor cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Research Foundation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LINEAGE-TRACING
dc.subject
NEURAL DIFFERENTIATION
dc.subject
SILAC
dc.subject
TGFBR2-KNOCKOUT
dc.subject
ASTRCYTE-DIVERSITY
dc.subject.classification
Biología del Desarrollo
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
TGFβ-signaling and FOXG1-expression are a hallmark of astrocyte lineage diversity in the murine ventral and dorsal forebrain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:39:40Z
dc.journal.volume
12
dc.journal.number
448
dc.journal.pagination
1-16
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Weise, Stefan Christopher. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Villarreal, Alejandro. Universität Freiburg Im Breisgau; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Heidrich, Stefanie. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Dehghanian, Fariba. University Of Isfahan; Irán. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Schachtrup, Christian. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Nestel, Sigrun. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Schwarz, Jennifer. Universität Freiburg Im Breisgau; Alemania
dc.description.fil
Fil: Thedieck, Kathrin. Universität Oldenburg; Argentina. University of Groningen; Países Bajos
dc.description.fil
Fil: Vogel, Tanja. Universität Freiburg Im Breisgau; Alemania
dc.journal.title
Frontiers in Cellular Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fncel.2018.00448/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncel.2018.00448
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